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Symbol
Name
ID
Htt
huntingtin
MGI:96067
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Cerebellar atrophy
Gliosis
Neuronal loss in central nervous system
Gait ataxia
Bradykinesia
Rigidity
Dementia
Hyperreflexia
Chorea
Depressivity
Personality changes
Seizures
Disease(s) Associated with HTT
Huntington's disease

Mouse Phenotypes
nervous system phenotype
seizures
tonic-clonic seizures
microgliosis
abnormal brain morphology
abnormal cerebellum development
exencephaly
hydrocephaly
decreased brain size
abnormal brain ventricle morphology
enlarged lateral ventricles
enlarged third ventricle
abnormal lateral ventricle morphology
dilated lateral ventricles
abnormal cerebral aqueduct morphology
abnormal anterior commissure morphology
abnormal brain internal capsule morphology
abnormal midbrain morphology
abnormal forebrain morphology
abnormal globus pallidus morphology
abnormal striatum morphology
abnormal dorsal striatum morphology
abnormal medium spiny neuron morphology
abnormal ventral striatum morphology
abnormal subthalamic nucleus morphology
abnormal thalamus morphology
abnormal hippocampus morphology
absent hippocampal fimbria
abnormal telencephalon morphology
abnormal cerebral cortex morphology
decreased neocortex volume
abnormal olfactory bulb morphology
abnormal postnatal subventricular zone morphology
brain atrophy
astrocytosis
decreased oligodendrocyte number
gliosis
abnormal embryonic/fetal subventricular zone morphology
abnormal nervous system tract morphology
abnormal neuron morphology
decreased myelin sheath thickness
neuron degeneration
neuronal intranuclear inclusions
neurodegeneration
abnormal nervous system physiology
abnormal oligodendrocyte physiology
abnormal myelination
dysmyelination
abnormal neuron physiology
Availability Mouse Genotype
Htttm1.1Tna/Htttm1.1Tna
Htttm1Detl/Htttm1Detl *
Htttm1Mfc/Htttm1Mfc
Htttm1Msl/Htttm1Msl *
Htttm2Detl/Htttm2Detl *
Htttm2Mem/Htttm2Mem *
Htttm2Msl/Htttm2Msl
Htttm3Mem/Htttm3Mem *
Htttm4Mem/Htttm4Mem
Htttm5Mem/Htttm5Mem *
Htttm7Mem/Htttm7Mem
Htttm1.1Pfs/Htt+
Htttm1.1Tna/Htt+
Htttm1Detl/Htt+ *
Htttm1Hay/Htt+
Htttm1Mem/Htttm6Mem
Htttm1Mem/Htttm7Mem
Htttm2.1Pfs/Htt+
Htttm2Detl/Htt+ *
Htttm4Mem/Htt+
Htttm5Mem/Htt+
Htttm6Mem/Htttm8Mem *
Htttm1Szi/Htttm2Szi
Tg(Camk2a-cre)1Szi/0  (conditional)
Htttm1Szi/Htttm2Szi
Tg(Camk2a-cre)2Szi/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory