Symbol
Name
ID

Htt
huntingtin
MGI:96067

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Depression	Apathy	Reduced social reciprocity	Personality changes	Impulsivity	Agitation	Restless legs
Disease(s) Associated with HTT	Depression	Apathy	Reduced social reciprocity	Personality changes	Impulsivity	Agitation	Restless legs
Huntington's disease
Parkinson's disease

Mouse Phenotypes

behavior/neurological phenotype

abnormal behavior

abnormal learning/memory/conditioning

abnormal motor learning

increased aggression towards mice

increased thigmotaxis

increased grooming behavior

abnormal motor capabilities/coordination/movement

limb grasping

tremors

abnormal motor coordination/balance

enhanced coordination

impaired balance

impaired coordination

impaired limb coordination

decreased grip strength

increased grip strength

hunched posture

straub tail

abnormal locomotor activation

abnormal locomotor coordination

abnormal gait

long stride length

short stride length

decreased vertical activity

increased vertical activity

decreased locomotor activity

increased locomotor activity

hyperactivity

bradykinesia

paralysis

hyperresponsive

seizures

environmentally induced seizures

tonic-clonic seizures

Availability

Mouse Genotype

Htt^tm1Detl/Htt^tm1Detl

Htt^tm1Mfc/Htt^tm1Mfc

Htt^tm2Detl/Htt^tm2Detl

Htt^tm4Mem/Htt^tm4Mem

Htt^tm5Mem/Htt^tm5Mem

Htt^tm6Mem/Htt^tm6Mem

Htt^em1(IMPC)H/Htt⁺

Htt^tm1.1Pfs/Htt⁺

Htt^tm1Detl/Htt⁺

Htt^tm1Hay/Htt⁺

Htt^tm1Mem/Htt^tm6Mem

Htt^tm2.1Pfs/Htt⁺

Htt^tm2Detl/Htt⁺

Htt^tm5Detl/Htt⁺

Htt^tm6Mem/Htt^tm8Mem

Htt^tm1Mem/Htt^tm6Mem
Tg(CAG-cre/Esr1*)5Amc/0 (conditional)

Htt^tm1Szi/Htt^tm2Szi
Tg(Camk2a-cre)1Szi/0 (conditional)

Htt^tm1Szi/Htt^tm2Szi
Tg(Camk2a-cre)2Szi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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