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protein tyrosine phosphatase, non-receptor type 6
Phenotype annotations related to immune system
Darker colors indicate more annotations

Mouse Phenotypes
decreased B cell proliferation
increased splenocyte proliferation
salivary gland inflammation
abnormal thymus morphology
abnormal thymus development
small thymus
thymus atrophy
decreased thymocyte number
decreased immature B cell number
abnormal T cell differentiation
abnormal CD8-positive, alpha-beta T cell differentiation
abnormal granulocyte morphology
increased neutrophil cell number
increased granulocyte number
abnormal leukocyte cell number
increased dendritic cell number
decreased mature B cell number
decreased B-1 B cell number
decreased B-2 B cell number
decreased follicular B cell number
decreased marginal zone B cell number
increased B-1 B cell number
increased B-1a cell number
increased B-1b cell number
increased plasma cell number
decreased B cell number
increased B cell number
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
increased effector memory CD4-positive, alpha-beta T cell number
increased central memory CD8 positive, alpha-beta T cell number
increased effector memory CD8-positive, alpha-beta T cell number
increased CD8-positive, alpha-beta memory T cell number
decreased CD8-positive, naive alpha-beta T cell number
increased T cell number
increased macrophage cell number
increased monocyte cell number
increased leukocyte cell number
abnormal plasma cell morphology
abnormal CD8-positive, alpha beta T cell morphology
abnormal microglial cell morphology
abnormal myeloid leukocyte morphology
enlarged spleen
abnormal immunoglobulin level
increased IgA level
decreased IgD level
increased IgG level
decreased IgM level
increased IgM level
increased immunoglobulin level
abnormal T cell physiology
increased microglial cell activation
abnormal circulating chemokine level
increased circulating interferon-gamma level
increased circulating interleukin-1 beta level
increased circulating interleukin-10 level
increased circulating interleukin-17 level
increased circulating interleukin-6 level
abnormal circulating serum amyloid protein level
abnormal immune system cell morphology
abnormal Peyer's patch morphology
enlarged lymph nodes
abnormal lymph organ size
abnormal immune system physiology
abnormal humoral immune response
autoimmune response
increased susceptibility to systemic lupus erythematosus
increased autoantibody level
increased anti-chromatin antibody level
rheumatoid arthritis
abnormal inflammatory response
chronic inflammation
increased inflammatory response
lung inflammation
interstitial pneumonia
skin inflammation
decreased susceptibility to bacterial infection
decreased susceptibility to bacterial infection induced morbidity/mortality
Availability Mouse Genotype
Ptpn6tm1Rsky/Ptpn6tm1Rsky  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory