Symbol
Name
ID

Ptpn6
protein tyrosine phosphatase, non-receptor type 6
MGI:96055

Phenotype annotations related to immune system

Darker colors indicate more annotations

Mouse Phenotypes

decreased B cell proliferation

increased splenocyte proliferation

salivary gland inflammation

abnormal thymus morphology

abnormal thymus development

small thymus

thymus atrophy

decreased thymocyte number

enlarged spleen

decreased immature B cell number

abnormal T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal granulocyte morphology

increased neutrophil cell number

increased granulocyte number

abnormal leukocyte cell number

increased dendritic cell number

decreased mature B cell number

decreased B-1 B cell number

decreased B-2 B cell number

decreased follicular B cell number

decreased marginal zone B cell number

increased B-1 B cell number

increased B-1a cell number

increased B-1b cell number

increased plasma cell number

decreased B cell number

increased B cell number

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased effector memory CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta memory T cell number

decreased CD8-positive, naive alpha-beta T cell number

increased T cell number

increased macrophage cell number

increased monocyte cell number

increased leukocyte cell number

abnormal plasma cell morphology

abnormal CD8-positive, alpha beta T cell morphology

abnormal microglial cell morphology

abnormal myeloid leukocyte morphology

abnormal immunoglobulin level

increased IgA level

decreased IgD level

increased IgG level

decreased IgM level

increased IgM level

increased immunoglobulin level

abnormal T cell physiology

increased microglial cell activation

abnormal circulating chemokine level

increased circulating interferon-gamma level

increased circulating interleukin-1 beta level

increased circulating interleukin-10 level

increased circulating interleukin-17 level

increased circulating interleukin-6 level

increased circulating serum amyloid protein level

abnormal immune system cell morphology

abnormal Peyer's patch morphology

enlarged lymph nodes

abnormal lymph organ size

abnormal immune system physiology

abnormal humoral immune response

autoimmune response

increased susceptibility to systemic lupus erythematosus

increased autoantibody level

increased anti-chromatin antibody level

rheumatoid arthritis

abnormal inflammatory response

chronic inflammation

increased inflammatory response

lung inflammation

interstitial pneumonia

skin inflammation

decreased susceptibility to bacterial infection

decreased susceptibility to bacterial infection induced morbidity/mortality

Availability

Mouse Genotype

Ptpn6^em1.1Shoy/Ptpn6^em1.1Shoy

Ptpn6^m1Amgn/Ptpn6^m1Amgn

Ptpn6^m1Anu/Ptpn6^m1Anu

Ptpn6^m1Btlr/Ptpn6^m1Btlr

Ptpn6^m3Btlr/Ptpn6^m3Btlr

Ptpn6^m4Btlr/Ptpn6^m4Btlr

Ptpn6^M5Btlr/Ptpn6^M5Btlr

Ptpn6^m6Btlr/Ptpn6^m6Btlr

Ptpn6^m7Btlr/Ptpn6^m7Btlr

Ptpn6^me-B2/Ptpn6^me-B2

Ptpn6^me-v/Ptpn6^me-v

Ptpn6^me/Ptpn6^me

Ptpn6^m3Btlr/Ptpn6⁺

Cd19^tm1(cre)Cgn/Cd19⁺
Ptpn6^tm1Rsky/Ptpn6^tm1Rsky (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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