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Symbol
Name
ID
Grn
granulin
MGI:95832
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Cerebral cortical atrophy
Lewy bodies
Neurofibrillary tangles
Cerebellar atrophy
Dilation of lateral ventricles
Gliosis
Neuronal loss in central nervous system
EEG abnormality
Ataxia
Parkinsonism
Apraxia
Memory impairment
Mental deterioration
Frontotemporal dementia
Progressive language deterioration
Aphasia
Dysphasia
Mutism
Repetitive compulsive behavior
Polyphagia
Apathy
Hallucinations
Hyperorality
Disinhibition
Hypersexuality
Perseveration
Personality changes
Agitation
Seizures
Generalized myoclonic seizures
Disease(s) Associated with GRN
Grn-related frontotemporal lobar degeneration with Tdp43 inclusions
neuronal ceroid lipofuscinosis 11

Mouse Phenotypes
nervous system phenotype
increased susceptibility to dopaminergic neuron neurotoxicity
microgliosis
abnormal microglial cell physiology
abnormal brain morphology
decreased brain weight
abnormal hypothalamus morphology
abnormal paraventricular hypothalamic nucleus morphology
abnormal supraoptic nucleus morphology
abnormal thalamus neuron morphology
tau protein deposits
astrocytosis
loss of dopaminergic neurons
abnormal neurite morphology
abnormal dendrite morphology
abnormal dendritic spine morphology
decreased dendritic spine density
abnormal retinal ganglion cell morphology
retinal ganglion cell degeneration
abnormal synapse morphology
neuronal cytoplasmic inclusions
nervous system inclusion bodies
neurodegeneration
abnormal nervous system physiology
abnormal hypothalamus secretion
abnormal neuron physiology
impaired synaptic plasticity
abnormal excitatory postsynaptic potential
reduced long term potentiation
Availability Mouse Genotype
Grntm1.1Aidi/Grntm1.1Aidi
Grntm1.1Far/Grntm1.1Far
Grntm1.1Geno/Grntm1.1Geno
Grntm1Blrl/Grntm1Blrl *
Grntm2.1Far/Grntm2.1Far
Grntm1.1Hiok/Grn+
Grntm1Far/Grntm1Far
Tg(ITGAM-cre)2781Gkl/0  (conditional)
Grntm1Far/Grntm1Far  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/16/2019
MGI 6.14
The Jackson Laboratory