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Symbol
Name
ID
Grn
granulin
MGI:95832
Phenotype annotations related to behavior/neurological
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Mutism
Polyphagia
Apathy
Hallucinations
Hyperorality
Disinhibition
Hypersexuality
Perseveration
Personality changes
Agitation
Disease(s) Associated with GRN
Grn-related frontotemporal lobar degeneration with Tdp43 inclusions

Mouse Phenotypes
behavior/neurological phenotype
impaired contextual conditioning behavior
abnormal spatial learning
abnormal long term spatial reference memory
increased fluid intake
polydipsia
increased food intake
decreased aggression towards males
increased aggression towards males
increased anxiety-related response
increased thigmotaxis
abnormal response to novel object
decreased grooming behavior
increased grooming behavior
impaired coordination
abnormal social investigation
Availability Mouse Genotype
Grntm1.1Aidi/Grntm1.1Aidi
Grntm1.1Geno/Grntm1.1Geno
Grntm1Blrl/Grntm1Blrl *
Grntm1Mni/Grntm1Mni
Grntm2.1Far/Grntm2.1Far
Grntm1.1Hiok/Grn+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory