Symbol
Name
ID

Lrp2
low density lipoprotein receptor-related protein 2
MGI:95794

Phenotype annotations related to vision/eye

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Cataract	Hypoplasia of the iris	Iris coloboma	Retinal detachment	Retinal dystrophy	Hypertelorism	Proptosis	Myopia	High myopia	Progressive visual loss
Disease(s) Associated with LRP2
Donnai-Barrow syndrome

Mouse Phenotypes

vision/eye phenotype

increased retina apoptosis

decreased retina ganglion cell number

abnormal retina bipolar cell morphology

abnormal optic nerve morphology

abnormal retina pigment epithelium morphology

abnormal retina pigmentation

abnormal eye morphology

abnormal placement of pupils

abnormal lens morphology

ocular hypotelorism

macrophthalmia

microphthalmia

abnormal posterior eye segment morphology

thin retina inner nuclear layer

thin retina inner plexiform layer

thin retina outer nuclear layer

decreased total retina thickness

abnormal sclera morphology

sclera thinning

anophthalmia

abnormal intraocular pressure

high myopia

Availability

Mouse Genotype

Lrp2^27SH/Lrp2^27SH

Lrp2^b2b2671Clo/Lrp2^b2b2671Clo

Lrp2^tm1Her/Lrp2^tm1Her

H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Lrp2^tm1Tew/Lrp2^tm1Tew (conditional)

Lrp2^tm1Tew/Lrp2^tm1Tew
Tg(GFAP-cre)25Mes/0 (conditional)

Foxg1^tm1(cre)Skm/Foxg1⁺
Lrp2^tm1Tew/Lrp2^tm1Tew (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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