Symbol Name ID |
Gli3
GLI-Kruppel family member GLI3 MGI:95729 |
Darker colors indicate more annotations |
Human Phenotypes | Abnormal calvaria morphology |
Frontal bossing |
Craniosynostosis |
Dolichocephaly |
Scaphocephaly |
Trigonocephaly |
Macrocephaly |
Metopic synostosis |
Delayed cranial suture closure |
Clinodactyly of the 5th finger |
Postaxial hand polydactyly |
Complete duplication of distal phalanx of the thumb |
Camptodactyly of finger |
Broad thumb |
Duplication of thumb phalanx |
Mesoaxial hand polydactyly |
Preaxial hand polydactyly |
Symphalangism affecting the phalanges of the hand |
Dysplastic distal thumb phalanges with a central hole |
Triphalangeal thumb |
Opposable triphalangeal thumb |
Postaxial foot polydactyly |
Broad hallux phalanx |
Duplication of phalanx of hallux |
Broad hallux |
Preaxial foot polydactyly |
Mesoaxial foot polydactyly |
Sandal gap |
Camptodactyly of toe |
Toe syndactyly |
1-3 toe syndactyly |
1-5 toe syndactyly |
2-3 toe syndactyly |
Oligodactyly |
Mesoaxial polydactyly |
Preaxial polydactyly |
Syndactyly |
3-4 finger syndactyly |
Short foot |
Abnormal metacarpal morphology |
Short 4th metacarpal |
Y-shaped metacarpals |
Short palm |
Hip dislocation |
Joint contracture of the hand |
Distal shortening of limbs |
Mesomelia |
Accelerated skeletal maturation |
Rib fusion |
Hemivertebrae |
Radial head subluxation |
Disease(s) Associated with GLI3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
Greig cephalopolysyndactyly syndrome | |||||||||||||||||||||||||||||||||||||||||||||||||||
Pallister-Hall syndrome | |||||||||||||||||||||||||||||||||||||||||||||||||||
polydactyly | |||||||||||||||||||||||||||||||||||||||||||||||||||
syndactyly |
Mouse Phenotypes | abnormal lambdoid suture morphology |
wide metopic suture |
wide sagittal suture |
abnormal cranium morphology |
abnormal basisphenoid bone morphology |
basisphenoid bone foramen |
small basisphenoid bone |
enlarged cranium |
abnormal neurocranium morphology |
abnormal interfrontal bone morphology |
absent neurocranium |
abnormal tooth development |
abnormal maxilla morphology |
abnormal palatine bone horizontal plate morphology |
absent epiglottis |
abnormal phalanx morphology |
brachyphalangia |
polyphalangy |
increased diameter of humerus |
short humerus |
absent radius |
bowed radius |
short radius |
increased diameter of radius |
absent ulna |
bowed ulna |
short ulna |
increased diameter of ulna |
short femur |
short fibula |
absent tibia |
bowed tibia |
short tibia |
camptomelia |
abnormal laryngeal cartilage morphology |
abnormal skeleton morphology |
abnormal long bone morphology |
short scapula |
abnormal sternum morphology |
sternebra fusion |
split sternal manubrium |
abnormal xiphoid process morphology |
short sternum |
abnormal spine curvature |
abnormal vertebrae morphology |
abnormal vertebral arch morphology |
vertebral fusion |
synostosis |
abnormal bone mineralization |
abnormal endochondral bone ossification |
failure of endochondral bone ossification |
premature lambdoid suture closure |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Gli3Pdn/Gli3Pdn | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Gli3TgBR/Gli3TgBR | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Gli3tm1.2Zllr/Gli3tm1.2Zllr | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Gli3tm1Urt/Gli3tm1Urt | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Gli3tm2Blnw/Gli3tm2Blnw | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Gli3Xt-2H/Gli3Xt-2H | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Gli3Xt-3H/Gli3Xt-3H | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Gli3Xt-5H/Gli3Xt-5H | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Gli3Xt-6H/Gli3Xt-6H | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Gli3Xt-J/Gli3Xt-J | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Gli3Xt-3H/Gli3+ | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Gli3Xt-J/Gli3+ | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Gli3tm3.1Blnw/Gli3tm3.1Blnw Tg(Prrx1-cre)1Cjt/0 (conditional) |
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Gli3tm3.1Blnw/Gli3+ Tg(Prrx1-cre)1Cjt/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/19/2024 MGI 6.23 |
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