About   Help   FAQ
Symbol
Name
ID
Gli3
GLI-Kruppel family member GLI3
MGI:95729
Phenotype annotations related to skeleton
Darker colors indicate more annotations
Human Phenotypes
Abnormal calvaria morphology
Frontal bossing
Craniosynostosis
Dolichocephaly
Scaphocephaly
Trigonocephaly
Macrocephaly
Metopic synostosis
Delayed cranial suture closure
Clinodactyly of the 5th finger
Postaxial hand polydactyly
Complete duplication of distal phalanx of the thumb
Camptodactyly of finger
Broad thumb
Duplication of thumb phalanx
Mesoaxial hand polydactyly
Preaxial hand polydactyly
Symphalangism affecting the phalanges of the hand
Dysplastic distal thumb phalanges with a central hole
Triphalangeal thumb
Opposable triphalangeal thumb
Postaxial foot polydactyly
Broad hallux phalanx
Duplication of phalanx of hallux
Broad hallux
Preaxial foot polydactyly
Mesoaxial foot polydactyly
Sandal gap
Camptodactyly of toe
Toe syndactyly
1-3 toe syndactyly
1-5 toe syndactyly
2-3 toe syndactyly
Oligodactyly
Mesoaxial polydactyly
Preaxial polydactyly
Syndactyly
3-4 finger syndactyly
Short foot
Abnormal metacarpal morphology
Short 4th metacarpal
Y-shaped metacarpals
Short palm
Hip dislocation
Joint contracture of the hand
Distal shortening of limbs
Mesomelia
Accelerated skeletal maturation
Rib fusion
Hemivertebrae
Radial head subluxation
Disease(s) Associated with GLI3
Greig cephalopolysyndactyly syndrome
Pallister-Hall syndrome
polydactyly
syndactyly

Mouse Phenotypes
abnormal lambdoid suture morphology
wide metopic suture
wide sagittal suture
abnormal cranium morphology
abnormal basisphenoid bone morphology
basisphenoid bone foramen
small basisphenoid bone
enlarged cranium
abnormal neurocranium morphology
abnormal interfrontal bone morphology
absent neurocranium
abnormal tooth development
abnormal maxilla morphology
abnormal palatine bone horizontal plate morphology
absent epiglottis
abnormal phalanx morphology
brachyphalangia
polyphalangy
increased diameter of humerus
short humerus
absent radius
bowed radius
short radius
increased diameter of radius
absent ulna
bowed ulna
short ulna
increased diameter of ulna
short femur
short fibula
absent tibia
bowed tibia
short tibia
camptomelia
abnormal laryngeal cartilage morphology
abnormal skeleton morphology
abnormal long bone morphology
short scapula
abnormal sternum morphology
sternebra fusion
split sternal manubrium
abnormal xiphoid process morphology
short sternum
abnormal spine curvature
abnormal vertebrae morphology
abnormal vertebral arch morphology
vertebral fusion
synostosis
abnormal bone mineralization
abnormal endochondral bone ossification
failure of endochondral bone ossification
premature lambdoid suture closure
Availability Mouse Genotype
Gli3Pdn/Gli3Pdn
Gli3TgBR/Gli3TgBR
Gli3tm1.2Zllr/Gli3tm1.2Zllr
Gli3tm1Urt/Gli3tm1Urt
Gli3tm2Blnw/Gli3tm2Blnw
Gli3Xt-2H/Gli3Xt-2H
Gli3Xt-3H/Gli3Xt-3H
Gli3Xt-5H/Gli3Xt-5H
Gli3Xt-6H/Gli3Xt-6H
Gli3Xt-J/Gli3Xt-J
Gli3Xt-3H/Gli3+
Gli3Xt-J/Gli3+
Gli3tm3.1Blnw/Gli3tm3.1Blnw
Tg(Prrx1-cre)1Cjt/0  (conditional)
Gli3tm3.1Blnw/Gli3+
Tg(Prrx1-cre)1Cjt/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory