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Symbol
Name
ID
Ghr
growth hormone receptor
MGI:95708
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Abnormality of metabolism/homeostasis
Hypercholesterolemia
Disease(s) Associated with GHR
familial hypercholesterolemia
Laron syndrome

Mouse Phenotypes
homeostasis/metabolism phenotype
decreased insulin secretion
abnormal blood homeostasis
decreased circulating glucose level
hypoglycemia
increased circulating glucose level
hyperglycemia
decreased circulating testosterone level
decreased circulating estradiol level
decreased circulating glucagon level
increased circulating corticosterone level
decreased circulating luteinizing hormone level
increased circulating prolactin level
decreased circulating insulin level
increased circulating insulin level
decreased circulating insulin-like growth factor I level
increased circulating insulin-like growth factor I level
increased circulating leptin level
increased circulating growth hormone level
decreased circulating thyroxine level
decreased circulating triiodothyronine level
abnormal circulating lipid level
decreased circulating HDL cholesterol level
decreased circulating LDL cholesterol level
decreased circulating VLDL cholesterol level
decreased circulating cholesterol level
increased circulating free fatty acid level
decreased circulating triglyceride level
increased circulating interleukin-6 level
increased circulating creatine kinase level
increased circulating serum albumin level
decreased body temperature
abnormal fluid regulation
impaired glucose tolerance
increased insulin sensitivity
decreased adiponectin level
increased adiponectin level
decreased triiodothyronine level
increased circulating chloride level
decreased liver triglyceride level
Availability Mouse Genotype
Ghrtm1.1Jero/Ghrtm1.1Jero
Ghrtm1Arge/Ghrtm1Arge
Ghrtm1Jjk/Ghrtm1Jjk
Ghrtm1Mwat/Ghrtm1Mwat
Ghrtm2Mwat/Ghrtm2Mwat
Ghrtm1.1Dlr/Ghrtm1.1Dlr
Tg(Ins2-cre)25Mgn/0  (conditional)
Ghrtm1.1Masp/Ghrtm1.1Masp
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
Ghrtm1c(KOMP)Wtsi/Ghrtm1c(KOMP)Wtsi
Tg(Fabp4-cre)1Rev/0  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory