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Symbol
Name
ID
Fbn1
fibrillin 1
MGI:95489
Phenotype annotations related to respiratory system
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Pulmonary artery dilatation
Emphysema
Pneumothorax
Disease(s) Associated with FBN1
Marfan syndrome

Mouse Phenotypes
abnormal lung vasculature morphology
hemothorax
lung hemorrhage
lung inflammation
alveolitis
abnormal lung morphology
abnormal lung development
impaired lung alveolus development
abnormal pulmonary neuroendocrine body morphology
increased number of pulmonary neuroendocrine bodies
dilated pulmonary alveolar ducts
abnormal pulmonary alveolus morphology
abnormal pulmonary alveolus wall morphology
overexpanded pulmonary alveoli
abnormal pulmonary interalveolar septum morphology
abnormal alveolar pore morphology
thick pulmonary interalveolar septum
abnormal respiratory bronchiole morphology
emphysema
abnormal bronchiole morphology
abnormal tracheal cartilage morphology
abnormal respiration
increased total lung capacity
respiratory distress
increased lung compliance
Availability Mouse Genotype
Fbn1tm1Rmz/Fbn1tm1Rmz
Fbn1tm2Rmz/Fbn1tm2Rmz
Fbn1tm3Rmz/Fbn1tm3Rmz
Fbn1tm1Hcd/Fbn1+
Fbn1tm1Lper/Fbn1+ !
Fbn1Tsk/Fbn1+
Fbn1tm1.1Itl/Fbn1tm3Rmz
Tg(CMV-cre)1Cgn/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory