Symbol
Name
ID

Fas
Fas cell surface death receptor
MGI:95484

Phenotype annotations related to cellular

Darker colors indicate more annotations

Human Phenotypes	Abnormal lymphocyte apoptosis	Decreased lymphocyte apoptosis	Increased circulating IgA level	Increased circulating IgE level	Decreased circulating IgG level	Increased circulating IgG level	Decreased circulating total IgM	Increased circulating IgM level	Decreased specific anti-polysaccharide antibody level	Increased circulating antibody level	Reduced delayed hypersensitivity
Disease(s) Associated with FAS
autoimmune lymphoproliferative syndrome

Mouse Phenotypes

increased mesangial cell number

abnormal apoptosis

decreased B cell apoptosis

increased T cell apoptosis

increased renal glomerulus apoptosis

decreased macrophage apoptosis

decreased neuron apoptosis

decreased apoptosis

decreased hepatocyte apoptosis

increased apoptosis

epidermal necrosis

focal hepatic necrosis

lymph node necrosis

impaired leukocyte tethering or rolling

abnormal leukocyte adhesion

abnormal T cell proliferation

increased kidney cell proliferation

Availability

Mouse Genotype

Fas^lpr/Fas^lpr

Fas^tm1Dlo/Fas^tm1Dlo

Fas^tm1Ach/Fas^tm1Ach
Tg(Itgax-cre,-EGFP)4097Ach/? (conditional)

Fas^tm1Cgn/Fas^tm1Cgn
Tg(Cd4-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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