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Symbol
Name
ID
Eng
endoglin
MGI:95392
Phenotype annotations related to cardiovascular system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Gastrointestinal hemorrhage
Hematemesis
Hematochezia
Melena
Cerebral hemorrhage
Subarachnoid hemorrhage
Spontaneous hematomas
Lip telangiectasia
Palate telangiectasia
Tongue telangiectasia
Nasal mucosa telangiectasia
Conjunctival telangiectasia
Abnormal cardiovascular system physiology
Hypertension
Portal hypertension
Pulmonary arterial hypertension
Pulmonary embolism
Right-to-left shunt
Congestive heart failure
High-output congestive heart failure
Ischemic stroke
Transient ischemic attack
Dilatation of celiac artery
Dilatation of mesenteric artery
Arteriovenous fistulas of celiac and mesenteric vessels
Venous varicosities of celiac and mesenteric vessels
Arteriovenous malformation
Peripheral arteriovenous fistula
Cerebral arteriovenous malformation
Gastrointestinal arteriovenous malformation
Hepatic arteriovenous malformation
Pulmonary arteriovenous malformation
Spinal arteriovenous malformation
Gastrointestinal angiodysplasia
Gastrointestinal telangiectasia
Abnormality of the cerebral vasculature
Retinal telangiectasia
Cavernous hemangioma
Visceral angiomatosis
Telangiectasia
Mucosal telangiectasiae
Nail bed telangiectasia
Telangiectasia of the skin
Fingerpad telangiectases
Disease(s) Associated with ENG
hereditary hemorrhagic telangiectasia

Mouse Phenotypes
cardiovascular system phenotype
abnormal blood vessel morphology
abnormal dorsal aorta morphology
abnormal carotid artery morphology
abnormal capillary morphology
cerebral arteriovenous malformation
abnormal intersomitic vessel morphology
abnormal vascular development
decreased angiogenesis
abnormal perineural vascular plexus morphology
abnormal vitelline vasculature morphology
absent vitelline blood vessels
abnormal vascular smooth muscle morphology
arteriovenous malformation
gastrointestinal arteriovenous malformation
atretic vasculature
thin myocardium
abnormal cardiac outflow tract development
abnormal heart development
abnormal heart looping
failure of heart looping
abnormal endocardium morphology
enlarged heart
abnormal heart ventricle morphology
pericardial edema
pericardial effusion
hemorrhage
internal hemorrhage
hemoperitoneum
ear telangiectases
neck telangiectases
tail telangiectases
abnormal vascular wound healing
absent heartbeat
Availability Mouse Genotype
Engtm1Dyl/Engtm1Dyl
Engtm1Hma/Engtm1Hma
Engtm1Mle/Engtm1Mle
Engtm2.2Hma/Engtm2.2Hma
Engtm1Hma/Eng+
Engtm1Mle/Eng+ *!
Engtm2.1Hma/Engtm2.1Hma  (conditional)
Engtm2.1Hma/Engtm2.1Hma
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+  (conditional)
Engtm2.1Hma/Engtm2.1Hma
Tg(Tal1-cre/ERT)1Jrg/0  (conditional)
Engtm2.1Hma/Engtm2.1Hma
Tg(Myh11-cre/ERT2)1Soff/0  (conditional)
*
Engtm2.1Hma/Engtm2.1Hma
Lyz2tm1(cre)Ifo/Lyz2+  (conditional)
*
Engtm2.1Hma/Engtm2.1Hma
Tg(Tagln-cre)1Her/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory