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Symbol
Name
ID
En1
engrailed 1
MGI:95389
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations

Mouse Phenotypes
nervous system phenotype
abnormal brain vasculature morphology
abnormal neuron differentiation
abnormal axon guidance
decreased rhombomere 1 size
microgliosis
decreased serotonin level
abnormal brain morphology
abnormal brain development
abnormal cerebellum development
abnormal cerebellar lobule formation
abnormal midbrain development
decreased midbrain size
abnormal choroid plexus morphology
abnormal brain commissure morphology
abnormal corpora quadrigemina morphology
abnormal inferior colliculus morphology
absent inferior colliculus
decreased inferior colliculus size
increased inferior colliculus size
decreased superior colliculus size
increased superior colliculus size
abnormal hindbrain morphology
abnormal cerebellum morphology
abnormal cerebellum anterior vermis morphology
decreased anterior vermis size
absent cerebellar lobules
abnormal cerebellum posterior vermis morphology
abnormal cerebellum vermis morphology
absent cerebellum
astrocytosis
abnormal innervation
abnormal neuron morphology
abnormal dopaminergic neuron morphology
decreased dopaminergic neuron number
ectopic dopaminergic neuron
decreased neuron number
abnormal serotonergic neuron morphology
abnormal synapse morphology
neuron degeneration
abnormal cranial nerve morphology
absent oculomotor nerve
absent trochlear nerve
abnormal CNS synaptic transmission
Availability Mouse Genotype
En1tm1(Wnt1)Wrst/En1tm1(Wnt1)Wrst
En1tm1Alj/En1tm1Alj ! ! ! !
En1tm1Alj/En1tm1Alj
Tg(Wnt1-En1)1Amc/0
En1tm1Gld/En1tm1Gld
En1tm2(cre)Gld/En1tm2(cre)Gld
En1tm2Alj/En1tm2Alj
En1tm3(En2)Alj/En1tm3(En2)Alj *
En1tm4(en)Alj/En1tm4(en)Alj
En1tm5(en)Alj/En1tm5(en)Alj *
En1tm1(Otx2)Wrst/En1+
En1tm1(PDGFB)Nist/En1+
En1tm1(Wnt1)Wrst/En1+
En1tm1.1(Wnt1)Wrst/En1+
En1tm2Alj/En1+ *
En1tm1(Tnf)Fpit/En1tm1(Tnf)Fpit  (conditional) *
En1tm2(cre)Wrst/En1tm8.1Alj  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory