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Symbol
Name
ID
Drd2
dopamine receptor D2
MGI:94924
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Torticollis
Writer's cramp
Myoclonus
Tremor
Agoraphobia
Anxiety
Depressivity
Obsessive-compulsive behavior
Disease(s) Associated with DRD2
myoclonic dystonia 11

Mouse Phenotypes
nervous system phenotype
increased susceptibility to pharmacologically induced seizures
adenohypophysis peliosis
increased susceptibility to neuronal excitotoxicity
increased susceptibility to dopaminergic neuron neurotoxicity
abnormal neuronal migration
abnormal pituitary gland morphology
abnormal adenohypophysis morphology
decreased gonadotroph cell number
decreased lactotroph cell size
increased lactotroph cell number
decreased somatotroph cell number
increased thyrotroph cell number
adenohypophysis hyperplasia
adenohypophysis hypertrophy
increased pituitary gland weight
enlarged pituitary gland
pituitary gland hyperplasia
abnormal melanotroph morphology
enlarged pituitary intermediate lobe
pituitary intermediate lobe hyperplasia
increased pituitary adenoma incidence
abnormal pituitary gland physiology
microgliosis
abnormal dopamine level
increased dopamine level
abnormal brain development
astrocytosis
abnormal GABAergic neuron morphology
decreased dopaminergic neuron number
abnormal astrocyte physiology
abnormal nervous system electrophysiology
abnormal single cell response
abnormal neuron physiology
abnormal CNS synaptic transmission
abnormal excitatory postsynaptic currents
abnormal inhibitory postsynaptic currents
abnormal prepulse inhibition
absent long term depression
abnormal synaptic dopamine release
Availability Mouse Genotype
Drd2tm1Ebo/Drd2tm1Ebo
Drd2tm1Low/Drd2tm1Low *
Drd2tm1Mok/Drd2tm1Mok
Drd2tm1Schm/Drd2tm1Schm
Drd2tm1(IL2RA)Koba/Drd2+
Drd2tm1.1Mrub/Drd2tm1.1Mrub
Slc6a3tm1.1(cre)Bkmn/Slc6a3+  (conditional)
Drd2tm1.1Mrub/Drd2tm1.1Mrub
Tg(Nes-cre)1Kln/?  (conditional)
Drd2tm1Srcmo/Drd2tm1Srcmo
Tg(GFAP-cre)25Mes/0  (conditional)
*
Drd2tm3.1Ebo/Drd2tm3.1Ebo
En1tm2(cre)Wrst/En1+  (conditional)
Drd2tm3.1Ebo/Drd2tm3.1Ebo
Tg(Drd1a-cre)AGsc/0  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory