About   Help   FAQ
Symbol
Name
ID
Cr2
complement receptor 2
MGI:88489
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Decreased circulating IgA level
Decreased circulating IgG level
Decreased circulating total IgM
Decreased antibody level in blood
Impaired T cell function
Autoimmune hemolytic anemia
Neutropenia
Neutropenia in presence of anti-neutropil antibodies
Lymphopenia
B lymphocytopenia
Leukopenia
Autoimmune thrombocytopenia
Recurrent sinusitis
Recurrent bronchitis
Conjunctivitis
Pericarditis
Lymphadenopathy
Follicular hyperplasia
Splenomegaly
Inflammation of the large intestine
Colitis
Otitis media
Chronic otitis media
Recurrent otitis media
Glomerulonephritis
Nephritis
Abnormality of the immune system
Psoriasiform dermatitis
Malar rash
Pneumonia
Recurrent pneumonia
Autoimmunity
Antinuclear antibody positivity
Antiphospholipid antibody positivity
Systemic lupus erythematosus
Immunodeficiency
Asthma
Recurrent infections
Recurrent bacterial infections
Recurrent respiratory infections
Meningitis
Disease(s) Associated with CR2
common variable immunodeficiency
systemic lupus erythematosus

Mouse Phenotypes
immune system phenotype
abnormal class switch recombination
abnormal memory B cell differentiation
decreased neutrophil cell number
decreased B-1a cell number
decreased follicular B cell number
increased marginal zone B cell number
decreased B cell number
abnormal B-1 B cell morphology
abnormal spleen germinal center morphology
decreased spleen germinal center number
decreased spleen germinal center size
abnormal B cell physiology
abnormal B cell activation
abnormal germinal center B cell physiology
decreased IgG1 level
decreased IgG2a level
decreased IgG2b level
decreased IgG2c level
decreased IgG3 level
decreased IgG level
decreased IgM level
increased IgM level
decreased immunoglobulin level
abnormal immune system morphology
abnormal adaptive immunity
abnormal humoral immune response
impaired humoral immune response
decreased tumor necrosis factor secretion
increased anti-double stranded DNA antibody level
increased susceptibility to bacterial infection
increased susceptibility to bacterial infection induced morbidity/mortality
Availability Mouse Genotype
Cr2M1Btlr/Cr2M1Btlr
Cr2tm1.1Jhws/Cr2tm1.1Jhws *
Cr2tm1Crr/Cr2tm1Crr *
Cr2tm1Hmo/Cr2tm1Hmo
Cr2tm1Tft/Cr2tm1Tft
Cr2tm2.1(HLA-A)Crr/Cr2tm2.1(HLA-A)Crr
Cr2tm2.1Jhws/Cr2tm2.1Jhws *

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory