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Symbol
Name
ID
Comp
cartilage oligomeric matrix protein
MGI:88469
Phenotype annotations related to skeleton
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Genu valgum
Genu varum
Short distal phalanx of finger
Small epiphyses of the phalanges of the hand
Short phalanx of finger
Finger joint hypermobility
Brachydactyly
Avascular necrosis of the capital femoral epiphysis
Flared femoral metaphysis
Broad femoral neck
Coxa vara
Short femoral neck
Radial metaphyseal irregularity
Ulnar metaphyseal irregularity
Metaphyseal irregularity
Metaphyseal widening
Short metacarpal
Carpal bone hypoplasia
Abnormal acetabulum morphology
Genu recurvatum
Knee joint hypermobility
Irregular carpal bones
Limited elbow extension
Ulnar deviation of the wrist
Limited shoulder movement
Joint hypermobility
Generalized joint hypermobility
Limitation of joint mobility
Joint stiffness
Limited hip movement
Limited hip extension
Ankle pain
Knee pain
Hand pain
Delayed epiphyseal ossification
Epiphyseal dysplasia
Fragmented epiphyses
Fragmented, irregular epiphyses
Irregular epiphyses
Small epiphyses
Short long bone
Arthralgia of the hip
Hip dysplasia
Spatulate ribs
Lumbar hyperlordosis
Kyphosis
Scoliosis
Hypoplasia of the odontoid process
Irregular vertebral endplates
Beaking of vertebral bodies
Ovoid vertebral bodies
Platyspondyly
Atlantoaxial dislocation
Osteoarthritis
Hip osteoarthritis
Disease(s) Associated with COMP
carpal tunnel syndrome 2
multiple epiphyseal dysplasia 1
pseudoachondroplasia

Mouse Phenotypes
skeleton phenotype
increased chondrocyte apoptosis
decreased chondrocyte proliferation
osteoarthritis
abnormal hip joint morphology
short femur
short tibia
abnormal tendon morphology
decreased tendon stiffness
abnormal long bone epiphyseal plate morphology
abnormal long bone epiphyseal plate proliferative zone
abnormal pelvic girdle bone morphology
abnormal ischium morphology
abnormal cartilage morphology
abnormal chondrocyte morphology
abnormal chondrocyte physiology
Availability Mouse Genotype
Comptm1Mbri/Comptm1Mbri
Comptm2.1Mbri/Comptm2.1Mbri *
Comptm1Mbri/Comp+
Comptm2.1Mbri/Comp+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory