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Symbol
Name
ID
Ctnnb1
catenin (cadherin associated protein), beta 1
MGI:88276
Phenotype annotations related to vision/eye
Darker colors indicate more annotations
Human Phenotypes
Retinal degeneration
Retinal hole
Optic atrophy
Vitreoretinopathy
Exudative vitreoretinopathy
Strabismus
Nystagmus
Hypermetropia
Disease(s) Associated with CTNNB1
autosomal dominant non-syndromic intellectual disability 19
exudative vitreoretinopathy 7

Mouse Phenotypes
abnormal retinal vasculature morphology
increased lens epithelium apoptosis
abnormal eye morphology
abnormal lens capsule morphology
ruptured lens capsule
abnormal lens development
abnormal lens epithelium morphology
disorganized secondary lens fibers
cataract
nuclear cataracts
small lens
abnormal optic eminence morphology
ocular hypertelorism
microphthalmia
absent eyelids
anophthalmia
Availability Mouse Genotype
Ctnnb1Bfc/Ctnnb1+
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Cryaa-cre)10Mlr/0  (conditional)
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Pdgfb-icre/ERT2)1Frut/0  (conditional)
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Tcfap2a-cre)1Will/0  (conditional)
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Cryaa-cre)10Mlr/?  (conditional)
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Cryaa-cre)39Mlr/?  (conditional)
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Tcfap2a-cre)1Will/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory