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complement component 3
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Membranoproliferative glomerulonephritis
Decreased serum complement C3
Decreased serum complement factor B
Decreased serum complement factor H
Decreased serum complement factor I
Systemic lupus erythematosus
Recurrent bacterial infections
Disease(s) Associated with C3
complement component 3 deficiency
hemolytic-uremic syndrome

Mouse Phenotypes
immune system phenotype
decreased susceptibility to autoimmune hemolytic anemia
decreased mast cell number
decreased neutrophil cell number
abnormal neutrophil morphology
decreased osteoclast cell number
abnormal spleen germinal center morphology
decreased spleen germinal center number
decreased spleen germinal center size
abnormal mast cell physiology
decreased circulating interleukin-6 level
decreased circulating tumor necrosis factor level
abnormal tumor necrosis factor level
abnormal immune system morphology
abnormal immune system physiology
abnormal cell-mediated immunity
abnormal humoral immune response
impaired complement alternative pathway
decreased susceptibility to induced arthritis
abnormal inflammatory response
brain inflammation
liver inflammation
increased susceptibility to bacterial infection
increased susceptibility to bacterial infection induced morbidity/mortality
Availability Mouse Genotype
C3tm1Crr/C3tm1Crr *

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory