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Symbol
Name
ID 		Bmp4
bone morphogenetic protein 4
MGI:88180
Phenotype annotations related to vision/eye
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Microcornea
Sclerocornea
Cataract
Iris coloboma
Chorioretinal coloboma
Retinal dystrophy
Anophthalmia
Microphthalmia
Coloboma
Nystagmus
Myopia
Photophobia
Blindness
Disease(s) Associated with BMP4
syndromic microphthalmia 6
tooth agenesis

Mouse Phenotypes
abnormal retina blood vessel pattern
abnormal optic nerve morphology
abnormal optic disk morphology
absent optic nerve
abnormal eye morphology
abnormal anterior eye segment morphology
abnormal iridocorneal angle
abnormal canal of Schlemm morphology
absent Schlemm's canal
abnormal line of Schwalbe morphology
absent trabecular meshwork
hypoplastic trabecular meshwork
abnormal iris morphology
abnormal placement of pupils
irregularly shaped pupil
mydriasis
iris hypoplasia
anterior iris synechia
abnormal cornea morphology
decreased cornea thickness
increased cornea thickness
corneal opacity
abnormal eye anterior chamber depth
abnormal lens induction
cataract
anterior cortical cataract
anterior subcapsular cataract
abnormal eye development
persistence of hyaloid vascular system
abnormal eye size
buphthalmos
microphthalmia
eyelids fail to open
eyelids open at birth
abnormal posterior eye segment morphology
abnormal retina morphology
thin retina ganglion layer
abnormal retina inner nuclear layer morphology
thin retina inner nuclear layer
abnormal retina outer nuclear layer morphology
abnormal retina photoreceptor layer morphology
decreased total retina thickness
retina detachment
abnormal vitreous body morphology
increased opacity of vitreous body
anophthalmia
abnormal eye electrophysiology
ocular hypertension
Availability Mouse Genotype
Bmp4tm1Blh/Bmp4tm1Blh
Bmp4tm3.1Blh/Bmp4tm3.1Blh
Bmp4tm3Blh/Bmp4tm3Blh
Bmp4tm1.1Jlch/Bmp4tm2Blh
Bmp4tm1b(EUCOMM)Hmgu/Bmp4+
Bmp4tm1Blh/Bmp4+ ! ! ! !
Bmp4tm1Blh/Bmp4tm3.1Blh
Bmp4tm2Blh/Bmp4+
Bmp4tm3Blh/Bmp4tm3Blh
Foxg1tm1(cre)Skm/Foxg1+  (conditional)
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(CAG-Bmp4,-EGFP)1Ypc/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory