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Symbol
Name
ID
Bmp2
bone morphogenetic protein 2
MGI:88177
Phenotype annotations related to skeleton
Darker colors indicate more annotations
Human Phenotypes
Chondrocalcinosis
Aplasia/Hypoplasia of the middle phalanx of the 2nd finger
Triangular shaped middle phalanx of the 2nd finger
Short 2nd finger
Radial deviation of the 2nd finger
Ulnar deviation of the 2nd finger
Aplasia/Hypoplasia of the middle phalanx of the 5th finger
Short middle phalanx of the 5th finger
Triangular shaped middle phalanx of the 5th finger
Clinodactyly of the 5th finger
Short middle phalanx of finger
Medially deviated second toe
Short hallux
Broad hallux
Hallux valgus
2-3 toe syndactyly
Type A2 brachydactyly
Short 2nd metacarpal
Short foot
Osteoporosis
Limitation of joint mobility
Arthropathy
Joint dislocation
Disease(s) Associated with BMP2
brachydactyly type A2
hemochromatosis type 1

Mouse Phenotypes
impaired osteoblast differentiation
decreased osteoclast cell number
absent deltoid tuberosity
short humerus
abnormal scapula morphology
decreased rib number
abnormal vertebral column morphology
small vertebrae
vertebral fusion
abnormal bone structure
decreased bone mineral content
decreased bone mineral density
decreased trabecular bone volume
decreased bone volume
decreased osteoblast cell number
abnormal trabecular bone morphology
decreased trabecular bone thickness
decreased bone mineralization
decreased bone ossification
fragile skeleton
Availability Mouse Genotype
Bmp2tm1(KOMP)Vlcg/Bmp2+
Bmp2tm1Cjt/Bmp2tm1Cjt
Tg(Prrx1-cre)1Cjt/0  (conditional)
Bmp2tm1.1Mis/Bmp2tm1.2Mis
Tg(Col1a1-cre)1Bek/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory