|
Symbol Name ID |
Bmp2
bone morphogenetic protein 2 MGI:88177 |
| Darker colors indicate more annotations |
| Human Phenotypes | Aplasia of the maxilla |
Enamel hypoplasia |
Aplasia/Hypoplasia of the middle phalanx of the 2nd finger |
Triangular shaped middle phalanx of the 2nd finger |
Short 2nd finger |
Radial deviation of the 2nd finger |
Ulnar deviation of the 2nd finger |
Aplasia/Hypoplasia of the middle phalanx of the 5th finger |
Short middle phalanx of the 5th finger |
Triangular shaped middle phalanx of the 5th finger |
Clinodactyly of the 5th finger |
Short middle phalanx of finger |
Short hallux |
Broad hallux |
Hallux valgus |
Medially deviated second toe |
2-3 toe syndactyly |
Type A2 brachydactyly |
Short foot |
Short 2nd metacarpal |
Abnormal metacarpophalangeal joint morphology |
Joint swelling |
Joint stiffness |
Stiff interphalangeal joints |
Osteoporosis |
Arthritis |
Arthropathy |
| Disease(s) Associated with BMP2 | |||||||||||||||||||||||||||
| brachydactyly type A2 | |||||||||||||||||||||||||||
| hemochromatosis type 1 | |||||||||||||||||||||||||||
| osteoporosis | |||||||||||||||||||||||||||
| tooth agenesis |
| Mouse Phenotypes | impaired osteoblast differentiation |
abnormal craniofacial bone morphology |
small Meckel's cartilage |
abnormal sphenoid bone morphology |
abnormal presphenoid bone morphology |
abnormal temporal bone zygomatic process morphology |
abnormal jaw morphology |
absent mandibular coronoid process |
small mandible |
mandible hypoplasia |
short mandible |
abnormal maxillary shelf morphology |
abnormal maxillary zygomatic process morphology |
maxilla hypoplasia |
micrognathia |
absent zygomatic bone |
decreased osteoclast cell number |
absent deltoid tuberosity |
short humerus |
abnormal scapula morphology |
decreased rib number |
abnormal vertebral column morphology |
small vertebrae |
vertebral fusion |
abnormal bone structure |
decreased bone mineral content |
decreased bone mineral density |
decreased trabecular bone volume |
decreased bone volume |
decreased osteoblast cell number |
abnormal trabecular bone morphology |
decreased trabecular bone thickness |
decreased bone mineralization |
decreased bone ossification |
fragile skeleton |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||
| Bmp2tm1(KOMP)Vlcg/Bmp2+ | ||||||||||||||||||||||||||||||||||||
| Bmp2tm1Cjt/Bmp2tm1Cjt Tg(Prrx1-cre)1Cjt/0 (conditional) |
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| Bmp2tm1Jfm/Bmp2tm1Jfm H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Bmp2tm1.1Mis/Bmp2tm1.2Mis Tg(Col1a1-cre)1Bek/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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