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Symbol
Name
ID
Bcl3
B cell leukemia/lymphoma 3
MGI:88140
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
decreased B cell apoptosis
decreased B cell proliferation
increased B cell proliferation
abnormal B cell differentiation
abnormal class switch recombination
decreased immature B cell number
decreased transitional stage T1 B cell number
decreased transitional stage T2 B cell number
abnormal transitional stage T3 B cell morphology
increased neutrophil cell number
abnormal dendritic cell number
increased plasmacytoid dendritic cell number
absent marginal zone B cells
decreased B-1 B cell number
decreased B-1a cell number
decreased B-1b cell number
decreased follicular B cell number
decreased marginal zone B cell number
increased B-1 B cell number
increased marginal zone B cell number
decreased B cell number
increased central memory CD4-positive, alpha-beta T cell number
decreased CD4-positive, alpha beta T cell number
decreased central memory CD8 positive, alpha-beta T cell number
increased CD8-positive, alpha-beta memory T cell number
increased CD8-positive, alpha-beta T cell number
increased lymphocyte cell number
decreased macrophage cell number
increased macrophage cell number
abnormal myeloid dendritic cell morphology
abnormal lymphocyte morphology
abnormal B-2 B cell morphology
abnormal follicular B cell morphology
abnormal metallophilic macrophage morphology
abnormal spleen marginal zone macrophage morphology
intermingled spleen red and white pulp
increased spleen weight
enlarged spleen
abnormal spleen B cell follicle morphology
absent spleen germinal center
decreased spleen germinal center size
abnormal B cell physiology
decreased IgD level
decreased IgE level
decreased IgG1 level
decreased IgG2a level
decreased IgG2b level
decreased IgG3 level
decreased IgG level
decreased IgM level
increased IgM level
abnormal cytotoxic T cell physiology
abnormal macrophage physiology
abnormal follicular dendritic cell morphology
abnormal Peyer's patch morphology
abnormal Peyer's patch follicle morphology
abnormal Peyer's patch T cell area morphology
abnormal Peyer's patch germinal center morphology
decreased Peyer's patch number
small Peyer's patches
abnormal lymph node B cell domain morphology
lymph node hypoplasia
abnormal humoral immune response
abnormal cytokine secretion
decreased interferon-gamma secretion
decreased interleukin-12 secretion
abnormal innate immunity
increased susceptibility to bacterial infection
increased susceptibility to parasitic infection
Availability Mouse Genotype
Bcl3m1Btlr/Bcl3m1Btlr
Bcl3m2Btlr/Bcl3m2Btlr
Bcl3m3Btlr/Bcl3m3Btlr
Bcl3tm1b(EUCOMM)Wtsi/Bcl3tm1b(EUCOMM)Wtsi
Bcl3tm1Rie/Bcl3tm1Rie
Bcl3tm1Rsch/Bcl3tm1Rsch
Bcl3tm1Sbn/Bcl3tm1Sbn
Bcl3tm1Ver/Bcl3tm1Ver *
Bcl3m1Btlr/Bcl3+
Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory