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Symbol
Name
ID
Apoe
apolipoprotein E
MGI:88057
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Neurofibrillary tangles
Long-tract signs
Alzheimer disease
Senile plaques
Parkinsonism
Apraxia
Cognitive impairment
Memory impairment
Dementia
Sleep-wake cycle disturbance
Parietal hypometabolism in FDG PET
Disease(s) Associated with APOE
Alzheimer's disease 2
Alzheimer's disease 4

Mouse Phenotypes
nervous system phenotype
abnormal kindling response
abnormal blood-brain barrier function
hypopituitarism
cochlear inner hair cell degeneration
cochlear outer hair cell degeneration
abnormal response to CNS ischemic injury
decreased cerebral infarction size
abnormal hippocampus morphology
abnormal cerebral cortex morphology
abnormal neuron morphology
abnormal myelin sheath morphology
abnormal dendrite morphology
abnormal synapse morphology
abnormal synaptic vesicle morphology
cochlear ganglion degeneration
abnormal sciatic nerve morphology
abnormal astrocyte physiology
Availability Mouse Genotype
Apoetm1Bres/Apoetm1Bres
Apoetm1Unc/Apoetm1Unc *
Apoetm2(APOE_i2)Sfu/Apoetm2(APOE_i2)Sfu

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory