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Symbol
Name
ID
Apoe
apolipoprotein E
MGI:88057
Phenotype annotations related to immune system
Darker colors indicate more annotations
Human Phenotypes
Sea-blue histiocytosis
Splenomegaly
Disease(s) Associated with APOE
sea-blue histiocytosis

Mouse Phenotypes
blood vessel inflammation
increased spleen weight
decreased follicular B cell number
decreased marginal zone B cell number
increased marginal zone B cell number
increased B cell number
abnormal T cell number
abnormal CD4-positive, alpha beta T cell number
increased T-helper 2 cell number
increased CD4-positive, alpha beta T cell number
decreased macrophage cell number
increased macrophage cell number
abnormal B cell activation
increased IgM level
increased immunoglobulin level
abnormal immune system morphology
abnormal immune system physiology
abnormal dendritic cell physiology
decreased susceptibility to type IV hypersensitivity reaction
abnormal cell-mediated immunity
abnormal immune serum protein physiology
decreased interferon-gamma secretion
increased susceptibility to systemic lupus erythematosus
increased autoantibody level
increased anti-nuclear antigen antibody level
increased anti-double stranded DNA antibody level
lung inflammation
increased susceptibility to parasitic infection
Availability Mouse Genotype
Apoetm1Unc/Apoetm1Unc
Apoetm1.1Mae/Apoetm1.1Mae
Tg(Fabp4-cre)1Rev/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory