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Symbol
Name
ID
Apoe
apolipoprotein E
MGI:88057
Phenotype annotations related to cardiovascular system
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Macular hemorrhage
Splenomegaly
Disease(s) Associated with APOE
age related macular degeneration 1
sea-blue histiocytosis

Mouse Phenotypes
abnormal susceptibility to atherosclerosis
decreased susceptibility to atherosclerosis
increased susceptibility to atherosclerosis
abnormal aorta wall morphology
abnormal kidney arterial blood vessel morphology
abnormal spiral modiolar artery morphology
spiral modiolar artery stenosis
arteriosclerosis
atherosclerotic lesions
dilated glomerular capillary
kidney microaneurysm
vascular stenosis
increased heart weight
cardiac hypertrophy
abnormal blood flow velocity
increased cardiac output
increased cardiac stroke volume
decreased systemic vascular resistance
abnormal blood vessel physiology
abnormal blood-brain barrier function
decreased vasodilation
blood vessel inflammation
Availability Mouse Genotype
Apoeshl/Apoeshl !
ApoeTg(rtTA)1Gaga/ApoeTg(rtTA)1Gaga
Apoetm1Bres/Apoetm1Bres
Apoetm1Unc/Apoetm1Unc
Apoetm1Unc/Apoetm1Unc
Tg(Cyp21a1-Apoe)614Fet/0
Apoetm1Unc/Apoetm1Unc
Tg(Cyp21a1-Apoe)619Fet/0
Apoetm4Mae/Apoetm4Mae
Apoetm1Lmh/Apoe+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory