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Symbol
Name
ID
Apoc3
apolipoprotein C-III
MGI:88055
Phenotype annotations related to homeostasis/metabolism
Darker colors indicate more annotations
Human Phenotypes
Decreased level of 1,5 anhydroglucitol in serum
Increased HDL cholesterol concentration
Decreased LDL cholesterol concentration
Increased LDL cholesterol concentration
Increased VLDL cholesterol concentration
Hypercholesterolemia
Hyperlipidemia
Hypertriglyceridemia
Hypotriglyceridemia
Elevated circulating apolipoprotein A-II concentration
Elevated circulating apolipoprotein B concentration
Hyperglycemia
Glucose intolerance
Diabetes mellitus
Type II diabetes mellitus
Impaired glucose tolerance
Ketoacidosis
Disease(s) Associated with APOC3
apolipoprotein C-III deficiency
coronary artery disease
familial combined hyperlipidemia
type 1 diabetes mellitus

Mouse Phenotypes
increased susceptibility to diet-induced obesity
abnormal blood homeostasis
increased circulating glucose level
increased circulating leptin level
increased circulating ketone body level
decreased circulating HDL cholesterol level
decreased circulating LDL cholesterol level
decreased circulating VLDL cholesterol level
decreased circulating cholesterol level
decreased circulating triglyceride level
decreased energy expenditure
insulin resistance
abnormal lipid homeostasis
lipidosis
Availability Mouse Genotype
Apoc3tm1Unc/Apoc3tm1Unc
Apoc3tm1Unc/Apoc3+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory