Symbol
Name
ID

Apc
APC, WNT signaling pathway regulator
MGI:88039

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes	Progressive macrocephaly	Delayed cranial suture closure	Back pain	Osteoma	Cerebellar calcifications
Disease(s) Associated with APC	Progressive macrocephaly	Delayed cranial suture closure	Back pain	Osteoma	Cerebellar calcifications
familial adenomatous polyposis 1
medulloblastoma
pancreatic cancer

Mouse Phenotypes

enhanced osteoblast differentiation

abnormal cranium morphology

absent upper incisors

abnormal tooth development

absent teeth

abnormal mandible morphology

absent mandible

acrania

abnormal humerus morphology

increased osteosarcoma incidence

increased osteoma incidence

scapular bone hypoplasia

absent sternum

abnormal rib morphology

short ribs

abnormal cartilage development

abnormal chondrocyte morphology

abnormal skeleton development

abnormal bone mineralization

abnormal endochondral bone ossification

Availability

Mouse Genotype

Apc^M1Tno/Apc⁺

Apc^Min/Apc^tm1Tno

Apc^tm1.1Tno/Apc^tm1Tno

Apc^tm1Rsmi/Apc^tm1Rsmi
Tg(Col2a1-cre)1Rsjo/0 (conditional)

Apc^tm2Rak/Apc^tm2Rak
Tg(KRT14-cre)8Brn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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