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Symbol
Name
ID

Apc
APC, WNT signaling pathway regulator
MGI:88039

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Elevated circulating hepatic transaminase concentration	Diabetes mellitus	Increased level of L-fucose in urine	Keloids	Cerebellar calcifications
Disease(s) Associated with APC	Elevated circulating hepatic transaminase concentration	Diabetes mellitus	Increased level of L-fucose in urine	Keloids	Cerebellar calcifications
familial adenomatous polyposis 1
medulloblastoma
pancreatic cancer
stomach cancer

Mouse Phenotypes		homeostasis/metabolism phenotype	abnormal autophagy	increased blood urea nitrogen level	increased circulating cholesterol level	increased circulating free fatty acids level	increased circulating triglyceride level	hyperlipidemia	increased circulating tumor necrosis factor level	increased prostaglandin level	increased incidence of tumors by chemical induction
Availability	Mouse Genotype	homeostasis/metabolism phenotype	abnormal autophagy	increased blood urea nitrogen level	increased circulating cholesterol level	increased circulating free fatty acids level	increased circulating triglyceride level	hyperlipidemia	increased circulating tumor necrosis factor level	increased prostaglandin level	increased incidence of tumors by chemical induction
	Apc^tm1Tno/Apc^tm1Tno
	Apc^Min/Apc⁺
	Apc^tm2Tno/Apc⁺
	Apc^tm1Kk/Apc^tm1Kk Tg(Lck-cre)1Cwi/? (conditional)
	Apc^tm1Tno/Apc^tm1Tno Tg(Cdh16-cre)91Igr/0 (conditional)
	Apc^tm2.1Cip/Apc⁺ Tg(Vil1-cre/ERT2)23Syr/0 (conditional)
	Apc^tm2Rak/Apc⁺ Tg(Car1-cre)5Flt/0 (conditional)	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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