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Symbol
Name
ID
Akt1
thymoma viral proto-oncogene 1
MGI:87986
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Abnormality of metabolism/homeostasis
Disease(s) Associated with AKT1
ovarian cancer

Mouse Phenotypes
homeostasis/metabolism phenotype
increased fatty acid oxidation
decreased susceptibility to diet-induced obesity
decreased circulating leptin level
decreased circulating thyroxine level
increased carbon dioxide production
increased oxygen consumption
decreased respiratory quotient
abnormal glucose homeostasis
abnormal gluconeogenesis
improved glucose tolerance
increased insulin sensitivity
increased circulating adiponectin level
decreased liver triglyceride level
increased basal metabolism
Availability Mouse Genotype
Akt1tm1Mbb/Akt1tm1Mbb
Akt1tm2.1Mbb/Akt1tm2.1Mbb
Akt1tm2Mbb/Akt1tm2Mbb
Tg(Nes-cre)1Kln/0  (conditional)
*
Akt1tm2Mbb/Akt1tm2Mbb
Tg(Ckmm-cre)5Khn/0  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory