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Symbol
Name
ID

Alpl
alkaline phosphatase, liver/bone/kidney
MGI:87983

Phenotype annotations related to craniofacial

Darker colors indicate more annotations

Human Phenotypes	Frontal bossing	Craniosynostosis	Decreased calvarial ossification	Dolichocephaly	Widely patent fontanelles and sutures	Large fontanelles	Abnormality of the dentition	Carious teeth	Premature loss of primary teeth	Premature loss of permanent teeth
Disease(s) Associated with ALPL	Frontal bossing	Craniosynostosis	Decreased calvarial ossification	Dolichocephaly	Widely patent fontanelles and sutures	Large fontanelles	Abnormality of the dentition	Carious teeth	Premature loss of primary teeth	Premature loss of permanent teeth
adult hypophosphatasia
childhood hypophosphatasia
hypophosphatasia
infantile hypophosphatasia

Mouse Phenotypes

abnormal parietal bone morphology

thin parietal bone

abnormal alveolar process morphology

abnormal tooth morphology

enlarged dental pulp chamber

abnormal odontoblast morphology

abnormal tooth development

abnormal cementum mineralization

abnormal dentin mineralization

abnormal tooth root development

abnormal cementum morphology

abnormal acellular cementum morphology

abnormal cellular cementum morphology

abnormal tooth root morphology

short tooth root

Availability

Mouse Genotype

Alpl^tm1Jlm/Alpl^tm1Jlm

Alpl^tm1Sor/Alpl^tm1Sor

Alpl^tm2.1Jlm/Alpl⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23