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Symbol
Name
ID
Card9
caspase recruitment domain family, member 9
MGI:2685628
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating total IgE level
Cutaneous anergy
Autoimmune hemolytic anemia
Hypereosinophilia
Lymphopenia
Recurrent sinusitis
Recurrent aphthous stomatitis
Recurrent bronchitis
Blepharitis
Lymphadenopathy
Hepatitis
Recurrent otitis media
Recurrent urinary tract infections
Abnormality of the immune system
Cutaneous abscess
Eczema
Seborrheic dermatitis
Folliculitis
Pustule
Recurrent skin infections
Chronic furunculosis
Recurrent cutaneous fungal infections
Chronic mucocutaneous candidiasis
Chronic oral candidiasis
Recurrent vulvovaginal candidiasis
Skin rash
Autoimmunity
Immune dysregulation
Immunodeficiency
Chronic tinea infection
Recurrent infections
Recurrent Staphylococcus aureus infections
Onychomycosis
Recurrent respiratory infections
Recurrent viral infections
Meningitis
Deep dermatophytosis
Disease(s) Associated with CARD9
chronic mucocutaneous candidiasis

Mouse Phenotypes
immune system phenotype
abnormal macrophage physiology
abnormal cytokine level
abnormal dendritic cell physiology
abnormal cytokine secretion
abnormal chemokine secretion
decreased interleukin-10 secretion
decreased interleukin-12b secretion
decreased interleukin-23 secretion
decreased interleukin-6 secretion
decreased tumor necrosis factor secretion
abnormal innate immunity
increased susceptibility to bacterial infection
increased susceptibility to fungal infection
Availability Mouse Genotype
Card9tm1Jrld/Card9tm1Jrld
Card9tm1Tks/Card9tm1Tks *
Card9tm1Xlin/Card9tm1Xlin

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory