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Symbol
Name
ID
Kmt2d
lysine (K)-specific methyltransferase 2D
MGI:2682319
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Autoimmune thrombocytopenia
Recurrent otitis media
Abnormality of immune system physiology
Recurrent aspiration pneumonia
Recurrent infections
Disease(s) Associated with KMT2D
Kabuki syndrome

Mouse Phenotypes
immune system phenotype
increased B cell proliferation
abnormal B cell differentiation
increased germinal center B cell number
decreased mature B cell number
decreased follicular B cell number
decreased B cell number
increased spleen germinal center number
increased spleen germinal center size
decreased IgG1 level
decreased IgM level
Availability Mouse Genotype
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Cd19tm1(cre)Cgn/Cd19+  (conditional)
*
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Ighg1tm1(cre)Cgn/Ighg1+  (conditional)
*
Kmt2dtm1.1Kaig/Kmt2d+
Cd19tm1(cre)Cgn/Cd19+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory