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microRNA 146
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
enlarged spleen
increased spleen weight
abnormal lymphopoiesis
myeloid hyperplasia
increased germinal center B cell number
increased plasma cell number
increased T follicular helper cell number
increased regulatory T cell number
decreased lymphocyte cell number
decreased monocyte cell number
decreased leukocyte cell number
abnormal spleen B cell follicle morphology
increased spleen germinal center number
increased spleen germinal center size
increased IgG1 level
increased IgG level
abnormal T cell activation
abnormal regulatory T cell physiology
abnormal macrophage physiology
increased macrophage nitric oxide production
increased circulating interleukin-1 beta level
increased circulating interleukin-10 level
increased circulating interleukin-6 level
increased circulating tumor necrosis factor level
enlarged lymph nodes
abnormal immune system physiology
decreased interferon-gamma secretion
increased interleukin-1 beta secretion
increased interleukin-6 secretion
increased tumor necrosis factor secretion
abnormal immune tolerance
increased anti-double stranded DNA antibody level
increased acute inflammation
increased susceptibility to endotoxin shock
increased susceptibility to bacterial infection induced morbidity/mortality
Availability Mouse Genotype
Mir146tm1.1Bal/Mir146tm1.1Bal !
Mir146tm2.1Bal/Mir146tm2.1Bal * !
Tg(Cr2-cre)3Cgn/0  (conditional)
Ighg1tm1(cre)Cgn/Ighg1+  (conditional)
Tg(CD2-icre)4Kio/0  (conditional)
Tg(Cd4-cre)1Cwi/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory