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Symbol
Name
ID
Mir146
microRNA 146
MGI:2676831
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations

Mouse Phenotypes
enlarged spleen
increased spleen weight
abnormal lymphopoiesis
myeloid hyperplasia
extramedullary hematopoiesis
anemia
abnormal bone marrow cell morphology/development
increased bone marrow cell number
decreased erythrocyte cell number
decreased hematocrit
decreased hemoglobin content
thrombocytopenia
increased germinal center B cell number
increased plasma cell number
increased T follicular helper cell number
increased regulatory T cell number
decreased lymphocyte cell number
decreased monocyte cell number
decreased leukocyte cell number
abnormal spleen B cell follicle morphology
increased spleen germinal center number
increased spleen germinal center size
increased IgG1 level
increased IgG level
abnormal T cell activation
abnormal regulatory T cell physiology
abnormal macrophage physiology
increased macrophage nitric oxide production
abnormal bone marrow cell physiology
Availability Mouse Genotype
Mir146tm1.1Bal/Mir146tm1.1Bal
Mir146tm2.1Bal/Mir146tm2.1Bal
Mir146tm1.1Lfl/Mir146tm1.1Lfl
Tg(Cr2-cre)3Cgn/0  (conditional)
Mir146tm1.1Lfl/Mir146tm1.1Lfl
Ighg1tm1(cre)Cgn/Ighg1+  (conditional)
Mir146tm1.1Lfl/Mir146tm1.1Lfl
Tg(CD2-icre)4Kio/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory