Symbol
Name
ID

Shank2
SH3 and multiple ankyrin repeat domains 2
MGI:2671987

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Lack of spontaneous play	Impaired ability to form peer relationships	Autism	Inflexible adherence to routines	Motor stereotypy	Restrictive behavior
Disease(s) Associated with SHANK2
autistic disorder

Mouse Phenotypes

behavior/neurological phenotype

abnormal behavior

abnormal learning/memory/conditioning

abnormal spatial learning

increased anxiety-related response

increased thigmotaxis

abnormal response to novelty

increased grooming behavior

abnormal motor capabilities/coordination/movement

impaired righting response

improved righting response

limb grasping

impaired coordination

abnormal voluntary movement

abnormal locomotor behavior

increased locomotor activity

hyperactivity

increased stereotypic behavior

abnormal pup retrieval

abnormal nest building behavior

abnormal sexual interaction

abnormal social investigation

abnormal vocalization

decreased vocalization

Availability

Mouse Genotype

Shank2^{em2(IMPC)Rbrc}/Shank2^{em2(IMPC)Rbrc}

Shank2^tm1.1Tmb/Shank2^tm1.1Tmb

Shank2^tm1Mgle/Shank2^tm1Mgle

Shank2^tm1.1Tmb/Shank2⁺

Shank2^tm1Mgle/Shank2⁺

Shank2^tm1.1Bcgen/Shank2^tm1.1Bcgen
Tg(Pcp2-cre)2Mpin/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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