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Symbol
Name
ID
Shank2
SH3 and multiple ankyrin repeat domains 2
MGI:2671987
Phenotype annotations related to behavior/neurological
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Attention deficit hyperactivity disorder
Aggressive behavior
Impaired ability to form peer relationships
Impaired use of nonverbal behaviors
Lack of peer relationships
Autism
Restrictive behavior
Impulsivity
Inflexible adherence to routines or rituals
Lack of spontaneous play
Disease(s) Associated with SHANK2
autistic disorder

Mouse Phenotypes
behavior/neurological phenotype
abnormal learning/memory/conditioning
abnormal spatial learning
increased anxiety-related response
abnormal response to novelty
increased grooming behavior
abnormal motor capabilities/coordination/movement
impaired righting response
improved righting response
limb grasping
impaired coordination
abnormal voluntary movement
hyperactivity
increased stereotypic behavior
abnormal pup retrieval
abnormal nest building behavior
abnormal sexual interaction
abnormal social investigation
abnormal vocalization
decreased vocalization
Availability Mouse Genotype
Shank2tm1.1Tmb/Shank2tm1.1Tmb
Shank2tm1Mgle/Shank2tm1Mgle
Shank2tm1.1Tmb/Shank2+
Shank2tm1Mgle/Shank2+ *
Shank2tm1.1Bcgen/Shank2tm1.1Bcgen
Tg(Pcp2-cre)2Mpin/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory