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Symbol
Name
ID
Tph2
tryptophan hydroxylase 2
MGI:2651811
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Hyperactivity
Attention deficit hyperactivity disorder
Disease(s) Associated with TPH2
attention deficit hyperactivity disorder

Mouse Phenotypes
nervous system phenotype
abnormal serotonin level
decreased serotonin level
abnormal paraventricular hypothalamic nucleus morphology
abnormal suprachiasmatic nucleus morphology
abnormal hippocampus morphology
abnormal serotonergic neuron morphology
abnormal autonomic nervous system physiology
abnormal nervous system electrophysiology
Availability Mouse Genotype
Tph2Arg447/Tph2Arg447
Tph2Pro447/Tph2Pro447
Tph2tm1.1Zfc/Tph2tm1.1Zfc
Tph2tm1.2Kpl/Tph2tm1.2Kpl *
Tph2tm1Bdr/Tph2tm1Bdr
Tph2tm1Dmkh/Tph2tm1Dmkh *
Tph2tm1Lex/Tph2tm1Lex
Tph2tm1Mca/Tph2tm1Mca
Tph2tm2.2Pasq/Tph2tm2.2Pasq
Tph2tm1Mca/Tph2+
Tph2tm1Pasq/Tph2tm1.1Pasq *
Tph2tm2.1Pasq/Tph2tm2.2Pasq
Tg(CMV-cre/ERT)1Ipc/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory