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Symbol
Name
ID
Flnb
filamin, beta
MGI:2446089
Phenotype annotations related to skeleton
Darker colors indicate more annotations
Human Phenotypes
Hypoplasia of dental enamel
Shallow orbits
Micrognathia
Hypoplasia of the maxilla
Malar flattening
Frontal bossing
Prominent occiput
Encephalocele
Short neck
Clinodactyly of the 5th finger
Short middle phalanx of finger
Tombstone-shaped proximal phalanges
Spatulate thumbs
Hitchhiker thumb
Sandal gap
Widened distal phalanges
Clubbing
Brachydactyly
Short metatarsal
Short femur
Club-shaped proximal femur
Distal tapering femur
Dumbbell-shaped femur
Fibular aplasia
Bipartite calcaneus
Tarsal synostosis
Tibial bowing
Radial bowing
Absent radius
Aplasia/Hypoplasia of the ulna
Bowed humerus
Short humerus
Short metacarpal
Flat acetabular roof
Hip dislocation
Knee dislocation
Multiple carpal ossification centers
Capitate-hamate fusion
Accessory carpal bones
Carpal synostosis
Elbow dislocation
Dislocated wrist
Micromelia
Rhizomelia
Epiphyseal dysplasia
Multinucleated giant chondrocytes in epiphyseal cartilage
Abnormality of pelvic girdle bone morphology
Short sacroiliac notch
Hypoplastic iliac body
11 pairs of ribs
Pectus carinatum
Pectus excavatum
Thoracic hypoplasia
Narrow chest
Horizontal sacrum
Beaking of vertebral bodies
Platyspondyly
Thoracic platyspondyly
Coronal cleft vertebrae
Hypoplastic cervical vertebrae
Vertebral segmentation defect
Cervical segmentation defect
Vertebral fusion
Block vertebrae
Fused cervical vertebrae
Cervical kyphosis
C2-C3 subluxation
Hyperlordosis
Lumbar hyperlordosis
Scoliosis
Hypoplasia of the odontoid process
Spondylolysis
Disproportionate short-trunk short stature
Joint laxity
Delayed skeletal maturation
Disease(s) Associated with FLNB
atelosteogenesis
Boomerang dysplasia
Larsen syndrome
spondylocarpotarsal synostosis syndrome

Mouse Phenotypes
abnormal neurocranium morphology
abnormal occipital bone morphology
abnormal parietal bone morphology
abnormal viscerocranium morphology
fused carpal bones
brachyphalangia
abnormal radius morphology
decreased diameter of radius
short radius
abnormal ulna morphology
decreased diameter of ulna
short tibia
abnormal patella morphology
abnormal limb bone morphology
abnormal long bone epiphyseal plate morphology
abnormal long bone epiphyseal plate proliferative zone
decreased width of hypertrophic chondrocyte zone
increased width of hypertrophic chondrocyte zone
decreased long bone epiphyseal plate size
decreased length of long bones
abnormal sternum morphology
abnormal sternebra morphology
abnormal thoracic cage morphology
decreased rib number
rib fusion
thin ribs
thoracic vertebral fusion
small thoracic cage
abnormal vertebral column morphology
absent intervertebral disk
kyphoscoliosis
kyphosis
lordosis
scoliosis
cervical vertebral fusion
vertebral fusion
decreased bone mineral content
decreased bone mineral density
decreased compact bone thickness
abnormal chondrocyte morphology
abnormal hyaline cartilage morphology
joint laxity
abnormal perichondrium morphology
abnormal skeleton development
abnormal bone ossification
abnormal bone mineralization
decreased bone mineralization
delayed endochondral bone ossification
delayed intramembranous bone ossification
decreased bone ossification
delayed bone ossification
abnormal chondrocyte physiology
Availability Mouse Genotype
FlnbGt(BGB085)Byg/FlnbGt(BGB085)Byg
FlnbGt(RRF239)Byg/FlnbGt(RRF239)Byg
FlnbGt(XD076)Byg/FlnbGt(XD076)Byg
Flnbskm2/Flnbskm2
Flnbtm1Vshn/Flnbtm1Vshn
Flnbtm1b(KOMP)Wtsi/Flnb+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory