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Symbol
Name
ID
Mavs
mitochondrial antiviral signaling protein
MGI:2444773
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
decreased B cell proliferation
increased dendritic cell number
decreased CD4-positive, alpha beta T cell number
decreased CD8-positive, alpha-beta T cell number
enlarged spleen
abnormal B cell physiology
decreased IgG1 level
decreased IgG2a level
increased IgG2a level
decreased IgG level
increased IgG level
increased IgM level
abnormal macrophage physiology
abnormal circulating interferon level
decreased circulating interferon-alpha level
decreased circulating interferon-beta level
decreased circulating interferon-gamma level
increased circulating interferon-gamma level
decreased circulating interleukin-6 level
increased circulating interleukin-6 level
increased circulating tumor necrosis factor level
abnormal dendritic cell physiology
abnormal cytokine secretion
decreased interferon-alpha secretion
decreased interferon-beta secretion
decreased interleukin-12 secretion
decreased interleukin-12b secretion
decreased interleukin-6 secretion
decreased tumor necrosis factor secretion
CNS inflammation
brain inflammation
abnormal innate immunity
abnormal response to infection
increased susceptibility to viral infection induced morbidity/mortality
increased susceptibility to viral infection
Availability Mouse Genotype
Mavstm1Aki/Mavstm1Aki *
Mavstm1Camb/Mavstm1Camb
Mavstm1Tsc/Mavstm1Tsc
Mavstm1Zjc/Mavstm1Zjc
Mavstm1Zjc/Mavs+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory