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Symbol
Name
ID 		Chd7
chromodomain helicase DNA binding protein 7
MGI:2444748
Phenotype annotations related to vision/eye
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Abnormality of the eye
Cataract
Iris coloboma
Chorioretinal coloboma
Optic atrophy
Retinal coloboma
Hypertelorism
Anophthalmia
Microphthalmia
Unilateral microphthalmos
Coloboma
Strabismus
Nystagmus
Abnormality of vision
Lacrimation abnormality
Ptosis
Disease(s) Associated with CHD7
CHARGE syndrome

Mouse Phenotypes
vision/eye phenotype
eyelid edema
blepharitis
conjunctivitis
keratoconjunctivitis sicca
decreased retina cone cell number
short retina cone cell outer segment
short retina rod cell outer segment
abnormal eye morphology
abnormal pupil morphology
abnormal lens development
cataract
small lens
abnormal eye development
abnormal optic cup morphology
absent optic cup
abnormal optic eminence morphology
coloboma
ocular hypertelorism
narrow eye opening
dry eyes
Availability Mouse Genotype
Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor
Chd7Coa1/Chd7+
Chd7Flo/Chd7+
Chd7Gt(S20-7E1)Sor/Chd7+
Chd7Looper/Chd7+
Chd7tm2a(EUCOMM)Wtsi/Chd7+
Chd7Trooper/Chd7+
Chd7Whi/Chd7+ *
Chd7tm1.1Dmm/Chd7tm1.1Dmm
Tg(rx3-icre)1Mjam/0  (conditional)
Chd7tm1.1Dmm/Chd7tm1.1Dmm
Foxg1tm1(cre)Skm/Foxg1+  (conditional)
Chd7tm1.1Dmm/Chd7tm1.1Dmm
Tg(Pax6-cre,GFP)1Pgr/0  (conditional)
Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm
Foxg1tm1(cre)Skm/Foxg1+  (conditional)
Chd7tm1.1Dmm/Chd7+
Tg(rx3-icre)1Mjam/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory