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Symbol
Name
ID
Nlgn3
neuroligin 3
MGI:2444609
Phenotype annotations related to behavior/neurological
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Attention deficit hyperactivity disorder
Aggressive behavior
Impaired ability to form peer relationships
Impaired use of nonverbal behaviors
Lack of peer relationships
Autism
Autism with high cognitive abilities
Restrictive behavior
Impulsivity
Inflexible adherence to routines or rituals
Lack of spontaneous play
Sleep disturbance
Disease(s) Associated with NLGN3
Asperger syndrome
autistic disorder

Mouse Phenotypes
behavior/neurological phenotype
abnormal behavior
abnormal learning/memory/conditioning
impaired contextual conditioning behavior
impaired cued conditioning behavior
abnormal spatial learning
enhanced learning
increased thigmotaxis
altered righting response
decreased startle reflex
abnormal motor coordination/balance
enhanced coordination
impaired coordination
decreased vertical activity
hyperactivity
hypoactivity
stereotypic behavior
increased stereotypic behavior
abnormal social investigation
decreased vocalization
Availability Mouse Genotype
Nlgn3em1(IMPC)Rbrc/Nlgn3em1(IMPC)Rbrc
Nlgn3tm1.1Htz/Nlgn3tm1.1Htz
Nlgn3tm1Bros/Nlgn3tm1Bros *
Nlgn3em1(IMPC)Rbrc/Y
Nlgn3tm1.1Htz/Y
Nlgn3tm1Rhn/Y
Nlgn3tm1Sud/Y
Nlgn3tm2.1Sud/Y
Nlgn3tm4.1Sud/Y
Pvalbtm1(cre)Arbr/Pvalb+  (conditional)
Nlgn3tm1Sud/Y
Tg(Drd1-cre)EY262Gsat/0  (conditional)
Nlgn3tm4.1Sud/Y
Tg(Nes-cre)1Kln/0  (conditional)
Nlgn3tm4.1Sud/Y
Tg(Pcp2-cre)2Mpin/0  (conditional)
Nlgn3tm4.1Sud/Y
Tg(Drd1-cre)EY262Gsat/0  (conditional)
Nlgn3tm4.1Sud/Y
Tg(Adora2a-cre)2MDkde/0  (conditional)
*
Nlgn3tm4.1Sud/Y  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory