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Symbol
Name
ID

Mfn2
mitofusin 2
MGI:2442230

Phenotype annotations related to limbs/digits/tail

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Tapered finger

Paresis of extensor muscles of the big toe

Hammertoe

Abnormal foot morphology

Pes cavus

Talipes equinovarus

Increased laxity of ankles

Areflexia of lower limbs

Absent patellar reflexes

Absent Achilles reflex

Distal lower limb muscle weakness

Hand muscle weakness

Triceps weakness

Upper limb amyotrophy

Limb muscle weakness

Foot dorsiflexor weakness

Quadriceps muscle weakness

Abnormality of the hand

Disease(s) Associated with MFN2

Charcot-Marie-Tooth disease type 2A2A

Charcot-Marie-Tooth disease type 2A2B

Charcot-Marie-Tooth disease type 6

multiple symmetric lipomatosis

Mouse Phenotypes		limbs/digits/tail phenotype	abnormal autopod morphology	abnormal hindlimb morphology	abnormal tail morphology	short tail	kinked tail
Availability	Mouse Genotype	limbs/digits/tail phenotype	abnormal autopod morphology	abnormal hindlimb morphology	abnormal tail morphology	short tail	kinked tail
	Tg(Mnx1-Mfn2T105M,-EGFP)1Dcc/Tg(Mnx1-Mfn2T105M,-EGFP)1Dcc
	Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc/0	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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