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Symbol
Name
ID
Wnk1
WNK lysine deficient protein kinase 1
MGI:2442092
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Abnormality of metabolism/homeostasis
Disease(s) Associated with WNK1
hereditary sensory and autonomic neuropathy type 2A

Mouse Phenotypes
homeostasis/metabolism phenotype
pericardial edema
increased circulating aldosterone level
decreased circulating potassium level
hyperkalemia
increased circulating sodium level
increased circulating angiotensinogen level
increased urine aldosterone level
increased circulating chloride level
increased urine potassium level
decreased urine sodium level
increased urine sodium level
metabolic acidosis
abnormal urine homeostasis
increased urine calcium level
decreased physiological sensitivity to xenobiotic
Availability Mouse Genotype
Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Wnk1tm1.1Juha/Wnk1tm1.1Juha
Wnk1tm2Cihu/Wnk1tm2Cihu
Wnk1Gt(OST38262)Lex/Wnk1+ *
Tg(Cdh16-Wnk1*)#Cihu/0
Wnk1tm1Clhu/Wnk1tm1Clhu
Tg(Tek-cre)12Flv/0  (conditional)
Wnk1tm2.1Juha/Wnk1+
Tg(Pgk1-cre)1Lni/0  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory