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Symbol
Name
ID
Tardbp
TAR DNA binding protein
MGI:2387629
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Dysphagia
Spasticity
Amyotrophic lateral sclerosis
Babinski sign
Frontotemporal dementia
Dysarthria
Stereotypy
Apathy
Disinhibition
Emotional lability
Perseveration
Disease(s) Associated with TARDBP
amyotrophic lateral sclerosis type 10

Mouse Phenotypes
nervous system phenotype
increased neuron apoptosis
increased microglial cell activation
abnormal brain interneuron morphology
decreased brain weight
decreased hippocampus volume
astrocytosis
gliosis
abnormal neuron morphology
abnormal GABAergic neuron morphology
abnormal motor neuron morphology
motor neuron degeneration
decreased neuron number
abnormal spinal cord ventral horn morphology
neurodegeneration
reduced long term potentiation
abnormal miniature excitatory postsynaptic currents
Availability Mouse Genotype
Tardbpem1Rhbr/Tardbpem1Rhbr *
Tg(Camk2a-Tardbp)#Ckjs/Tg(Camk2a-Tardbp)#Ckjs
Tardbpm1H/Tardbp+ *
Mnx1tm4(cre)Tmj/Mnx1+
Tardbptm1.1Ckjs/Tardbptm1.2Cjks  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory