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Symbol
Name
ID
Fgd4
FYVE, RhoGEF and PH domain containing 4
MGI:2183747
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Decreased number of peripheral myelinated nerve fibers
Onion bulb formation
Peripheral demyelination
Decreased motor nerve conduction velocity
Distal sensory impairment
Areflexia
Hyporeflexia
Waddling gait
Motor delay
Disease(s) Associated with FGD4
Charcot-Marie-Tooth disease type 4H

Mouse Phenotypes
nervous system phenotype
abnormal myelin sheath morphology
abnormal myelination
demyelination
abnormal nervous system electrophysiology
abnormal action potential
decreased nerve conduction velocity
Availability Mouse Genotype
Fgd4tm1.1Ics/Fgd4tm1.1Ics
Fgd4tm1Ics/Fgd4tm1Ics
Tg(Dhh-cre)1Mejr/0  (conditional)
Fgd4tm1Ics/Fgd4tm1Ics
Mnx1tm4(cre)Tmj/Mnx1+  (conditional)
*
Fgd4tm1Ics/Fgd4tm1Ics
Tg(Plp1-cre/ERT2)1Ueli/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory