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Symbol
Name
ID
Dicer1
dicer 1, ribonuclease type III
MGI:2177178
Phenotype annotations related to renal/urinary system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Renal cell carcinoma
Disease(s) Associated with DICER1
multinodular goiter

Mouse Phenotypes
renal/urinary system phenotype
abnormal renal tubule epithelial cell primary cilium morphology
increased kidney apoptosis
increased kidney cell proliferation
decreased urine osmolality
increased urine protein level
albuminuria
decreased susceptibility to kidney reperfusion injury
abnormal kidney morphology
decreased kidney collecting duct number
abnormal renal corpuscle morphology
dilated renal glomerular capsule
abnormal renal glomerulus morphology
kidney cortex cysts
renal interstitial fibrosis
decreased kidney weight
dilated renal tubules
pale kidney
decreased renal glomerular filtration rate
isosthenuria
polyuria
Availability Mouse Genotype
Dicer1tm1Bdh/Dicer1tm1Bdh
Hprttm1(Pck1-cre)Vhh/Y  (conditional)
*
Dicer1tm1Smr/Dicer1tm1Smr
Pax8tm1.1(cre)Mbu/Pax8+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory