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Symbol
Name
ID
Dicer1
dicer 1, ribonuclease type III
MGI:2177178
Phenotype annotations related to neoplasm
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Colorectal polyposis
Thyroid carcinoma
Papillary thyroid carcinoma
Sertoli cell neoplasm
Testicular seminoma
Ovarian neoplasm
Renal cell carcinoma
Pilomatrixoma
Basal cell carcinoma
Rhabdomyosarcoma
Alveolar rhabdomyosarcoma
Medulloblastoma
Cerebellar medulloblastoma
Pleuropulmonary blastoma
Medulloepithelioma
Disease(s) Associated with DICER1
multinodular goiter
pleuropulmonary blastoma

Mouse Phenotypes
neoplasm
increased facial tumor incidence
increased leukemia incidence
increased myeloid sarcoma incidence
increased hemolymphoid system tumor incidence
Availability Mouse Genotype
Dicer1tm1Mmk/Dicer1tm1Mmk
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0  (conditional)
Dicer1tm1Snj/Dicer1tm1Snj
Tg(KRT5-cre/PGR)1Der/0  (conditional)
*
Dicer1tm1Tara/Dicer1tm1Tara
Amhr2tm3(cre)Bhr/Amhr2+  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/17/2019
MGI 6.14
The Jackson Laboratory