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Symbol
Name
ID
Dicer1
dicer 1, ribonuclease type III
MGI:2177178
Phenotype annotations related to hematopoietic system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
hematopoietic system phenotype
increased T cell apoptosis
abnormal granulocyte differentiation
abnormal megakaryocyte differentiation
decreased T cell proliferation
abnormal thymus morphology
abnormal thymus development
abnormal thymus epithelium morphology
abnormal thymus cortex morphology
abnormal thymus medulla morphology
athymia
decreased thymocyte number
abnormal thymus physiology
abnormal thymus involution
decreased immature B cell number
abnormal immunoglobulin V(D)J recombination
increased pro-B cell number
arrested B cell differentiation
abnormal positive T cell selection
extramedullary hematopoiesis
anemia
impaired hematopoiesis
increased bone marrow cell number
abnormal megakaryocyte morphology
decreased red blood cell distribution width
decreased neutrophil cell number
abnormal neutrophil morphology
thrombocytopenia
giant platelets
decreased germinal center B cell number
decreased mature B cell number
absent memory B cells
absent plasma cells
increased B-1 B cell number
decreased B cell number
decreased pre-B cell number
increased effector memory CD4-positive, alpha-beta T cell number
decreased CD4-positive, alpha beta T cell number
increased central memory CD8 positive, alpha-beta T cell number
increased effector memory CD8-positive, alpha-beta T cell number
decreased CD8-positive, naive alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
increased gamma-delta T cell number
decreased regulatory T cell number
decreased T cell number
decreased single-positive T cell number
decreased leukocyte cell number
abnormal effector T cell morphology
abnormal regulatory T cell morphology
abnormal myeloid leukocyte morphology
decreased spleen weight
enlarged spleen
abnormal splenic cell ratio
abnormal germinal center B cell physiology
decreased immunoglobulin level
abnormal CD4-positive, alpha-beta T cell physiology
abnormal T-helper 1 physiology
abnormal T-helper 2 physiology
abnormal cytotoxic T cell physiology
abnormal regulatory T cell physiology
Availability Mouse Genotype
Dicer1m1Btlr/Dicer1m1Btlr
Dicer1tm1b(EUCOMM)Wtsi/Dicer1+
Dicer1tm1Bdh/Dicer1tm1Bdh
Tg(Cd4-cre)1Cwi/0  (conditional)
Dicer1tm1Bdh/Dicer1tm1Bdh
Foxp3tm4(YFP/icre)Ayr/Y  (conditional)
Dicer1tm1Bdh/Dicer1tm1Bdh
Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr  (conditional)
Dicer1tm1Bdh/Dicer1tm1Bdh
Tg(Foxp3-EGFP/icre)1aJbs/0  (conditional)
Dicer1tm1Bdh/Dicer1tm1Bdh
H2afvTg(Wnt1-cre)11Rth/0  (conditional)
Aicdatm1(cre)Njen/Aicda+
Dicer1tm1Bdh/Dicer1tm1Bdh  (conditional)
Dicer1tm1Dli/Dicer1tm1Dli
Tg(Cd4-cre)1Cwi/?  (conditional)
Dicer1tm1Mmk/Dicer1tm1Mmk
Tg(Lck-cre)1Cwi/0  (conditional)
Dicer1tm1Mmk/Dicer1tm1Mmk
Cd79atm1(cre)Reth/Cd79a+  (conditional)
Dicer1tm1Mmk/Dicer1tm1Mmk
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0  (conditional)
*
Dicer1tm1Mmk/Dicer1tm1Mmk
Tg(BGLAP-cre)1Clem/0  (conditional)
*
Dicer1tm1Tara/Dicer1tm1Tara
Foxn1tm3(cre)Nrm/Foxn1+  (conditional)
Dicer1tm1Mmk/Dicer1tm1.1Mmk
Cd79atm1(cre)Reth/Cd79a+  (conditional)
Dicer1tm1Bdh/Dicer1+
H2afvTg(Wnt1-cre)11Rth/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory