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Symbol
Name
ID
Tmc1
transmembrane channel-like gene family 1
MGI:2151016
Phenotype annotations related to hearing/vestibular/ear
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Sensorineural hearing impairment
Tinnitus
Disease(s) Associated with TMC1
autosomal dominant nonsyndromic deafness 36
autosomal recessive nonsyndromic deafness 7

Mouse Phenotypes
hearing/vestibular/ear phenotype
abnormal ear morphology
abnormal outer hair cell stereociliary bundle morphology
cochlear inner hair cell degeneration
cochlear outer hair cell degeneration
cochlear hair cell degeneration
abnormal scala media morphology
abnormal organ of Corti supporting cell morphology
abnormal Deiters cell morphology
Deiters cell degeneration
organ of Corti degeneration
abnormal stria vascularis morphology
abnormal tectorial membrane morphology
cochlear degeneration
vestibular saccular macula degeneration
abnormal otolith morphology
abnormal hair cell mechanoelectric transduction
abnormal hearing physiology
increased or absent threshold for auditory brainstem response
impaired hearing
deafness
Availability Mouse Genotype
Tmc1baringo/Tmc1baringo
Tmc1dn/Tmc1dn
Tmc1nice/Tmc1nice
Tmc1stitch/Tmc1stitch *!
Tmc1tm1.1Ajg/Tmc1tm1.1Ajg
Tmc1dn/Tmc1+ *
Tmc1Mhdabth/Tmc1+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory