Symbol
Name
ID

Tmc1
transmembrane channel-like gene family 1
MGI:2151016

Phenotype annotations related to hearing/vestibular/ear

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Abnormal vestibular function	Sensorineural hearing impairment	Tinnitus
Disease(s) Associated with TMC1	Abnormal vestibular function	Sensorineural hearing impairment	Tinnitus
autosomal dominant nonsyndromic deafness 36
autosomal recessive nonsyndromic deafness 7

Mouse Phenotypes

hearing/vestibular/ear phenotype

abnormal ear morphology

abnormal outer hair cell stereociliary bundle morphology

cochlear inner hair cell degeneration

cochlear outer hair cell degeneration

cochlear hair cell degeneration

abnormal scala media morphology

abnormal organ of Corti supporting cell morphology

abnormal Deiters cell morphology

Deiters cell degeneration

organ of Corti degeneration

abnormal stria vascularis morphology

abnormal tectorial membrane morphology

cochlear degeneration

vestibular saccular macula degeneration

abnormal otolith morphology

abnormal hair cell mechanoelectric transduction

abnormal hearing physiology

increased or absent threshold for auditory brainstem response

impaired hearing

deafness

Availability

Mouse Genotype

Tmc1^baringo/Tmc1^baringo

Tmc1^dn/Tmc1^dn

Tmc1^nice/Tmc1^nice

Tmc1^stitch/Tmc1^stitch

Tmc1^tm1.1Ajg/Tmc1^tm1.1Ajg

Tmc1^dn/Tmc1⁺

Tmc1^Mhdabth/Tmc1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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