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Symbol
Name
ID
Fig4
FIG4 phosphoinositide 5-phosphatase
MGI:2143585
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Microcephaly
Frequent falls
Onion bulb formation
Peripheral hypomyelination
Amyotrophic lateral sclerosis
Decreased motor nerve conduction velocity
Decreased nerve conduction velocity
Axonal loss
Distal sensory impairment
Pachygyria
Agenesis of corpus callosum
Arrhinencephaly
Cerebellar hypoplasia
Upper motor neuron dysfunction
Areflexia
Hyporeflexia
Gait disturbance
Bulbar signs
Severe global developmental delay
Motor delay
Disease(s) Associated with FIG4
amyotrophic lateral sclerosis type 11
Charcot-Marie-Tooth disease type 4J
Yunis-Varon syndrome

Mouse Phenotypes
nervous system phenotype
abnormal nervous system morphology
abnormal brain morphology
hydrocephaly
enlarged lateral ventricles
astrocytosis
abnormal motor neuron morphology
abnormal myelin sheath morphology
neuron degeneration
abnormal sciatic nerve morphology
neurodegeneration
spongiform encephalopathy
demyelination
abnormal action potential
abnormal nerve conduction
decreased nerve conduction velocity
Availability Mouse Genotype
Fig4plt1/Fig4plt1
Fig4plt1/Fig4plt1
Tg(ACTB-Fig4*I41T)705Mm/0
*
Fig4plt1/Fig4plt1
Tg(ACTB-Fig4*I41T)721Mm/0
*
Fig4plt1/Fig4plt1
Tg(Eno2-Fig4)#Mm/?
*
Fig4plt1/Fig4plt1
Tg(GFAP-Fig4)#Mm/?
*
Fig4tm1.1Mm/Fig4tm1.1Mm
Tg(Syn1-cre)671Jxm/?  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory