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Symbol
Name
ID
Wwox
WW domain-containing oxidoreductase
MGI:1931237
Phenotype annotations related to skeleton
Darker colors indicate more annotations
Human Phenotypes
Microcephaly
Disease(s) Associated with WWOX
autosomal recessive spinocerebellar ataxia 12

Mouse Phenotypes
abnormal osteoblast differentiation
abnormal osteoclast physiology
increased osteosarcoma incidence
increased skeletal tumor incidence
abnormal skeleton morphology
decreased bone mineral density
decreased trabecular bone volume
abnormal compact bone morphology
decreased compact bone area
decreased compact bone thickness
decreased osteoblast cell number
abnormal trabecular bone morphology
decreased bone trabecula number
decreased trabecular bone connectivity density
decreased trabecular bone thickness
abnormal skeleton development
increased bone resorption
Availability Mouse Genotype
Wwoxtm1.1Mald/Wwoxtm1.1Mald
Wwoxtm1Ria/Wwoxtm1Ria
Wwoxtm2.1Ria/Wwoxtm2.1Ria

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory