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Symbol
Name
ID
Wwox
WW domain-containing oxidoreductase
MGI:1931237
Phenotype annotations related to nervous system
Darker colors indicate more annotations
Human Phenotypes
Microcephaly
Progressive microcephaly
Spasticity
Delayed myelination
Hypoplasia of the corpus callosum
Cerebral atrophy
Cerebellar atrophy
Ataxia
Gait ataxia
Limb ataxia
Rigidity
Babinski sign
Intellectual disability
Dysarthria
Hyperreflexia
Hyporeflexia
Hypokinesia
Epileptic encephalopathy
Global developmental delay
Seizure
Disease(s) Associated with WWOX
autosomal recessive spinocerebellar ataxia 12
early infantile epileptic encephalopathy 28

Mouse Phenotypes
increased pituitary gland weight
abnormal pituitary gland physiology
increased brain weight
Availability Mouse Genotype
Wwoxtm1.1Mald/Wwoxtm1.1Mald
Wwoxtm1Ria/Wwoxtm1Ria

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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Funding Information
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory