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Symbol
Name
ID
Shank3
SH3 and multiple ankyrin repeat domains 3
MGI:1930016
Phenotype annotations related to behavior/neurological
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Feeding difficulties
Atypical behavior
Reduced social reciprocity
Autistic behavior
Autism
Aggressive behavior
Hyperactivity
Abnormal repetitive mannerisms
Bruxism
Tongue thrusting
Hair-pulling
Hyperorality
Disease(s) Associated with SHANK3
Phelan-McDermid syndrome
schizophrenia 15

Mouse Phenotypes
behavior/neurological phenotype
abnormal behavior
photophobia
decreased susceptibility to pharmacologically induced seizures
abnormal learning/memory/conditioning
abnormal conditioned emotional response
enhanced contextual conditioning behavior
impaired contextual conditioning behavior
enhanced cued conditioning behavior
abnormal habituation to a novel odor
impaired discrimination learning
abnormal motor learning
abnormal object recognition memory
abnormal long-term object recognition memory
abnormal response to new environment
decreased exploration in new environment
abnormal spatial learning
impaired spatial learning
abnormal spatial reference memory
impaired learning
premature suckling reflex loss
increased aggression towards mice
decreased anxiety-related response
increased anxiety-related response
increased thigmotaxis
increased fear-related response
abnormal innate avoidance response
abnormal response to novelty
abnormal response to novel object
abnormal response to social novelty
abnormal allogrooming behavior
increased grooming behavior
abnormal impulsive behavior control
abnormal motor capabilities/coordination/movement
abnormal reflex
abnormal righting response
impaired righting response
hyporesponsive to tactile stimuli
abnormal startle reflex
decreased startle reflex
increased startle reflex
abnormal motor coordination/balance
impaired coordination
decreased grip strength
weakness
abnormal locomotor activation
abnormal gait
long stride length
decreased vertical activity
increased vertical activity
decreased locomotor activity
increased locomotor activity
hyperactivity
induced hyperactivity
circling
decreased stereotypic behavior
increased stereotypic behavior
decreased thermal nociceptive threshold
abnormal social/conspecific interaction behavior
abnormal nest building behavior
abnormal sexual interaction
abnormal social investigation
abnormal social recognition
social withdrawal
abnormal vocalization
decreased vocalization
excessive vocalization
environmentally induced seizures
Availability Mouse Genotype
Shank3em1Hzo/Shank3em1Hzo
Shank3tm1.1Cya/Shank3tm1.1Cya *
Shank3tm1.1Geno/Shank3tm1.1Geno
Shank3tm1.1Pfw/Shank3tm1.1Pfw *
Shank3tm1.2Bux/Shank3tm1.2Bux *! !
Shank3tm1.2Yhj/Shank3tm1.2Yhj
Shank3tm1Cmpl/Shank3tm1Cmpl
Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp *
Shank3tm1Gfng/Shank3tm1Gfng *
Shank3tm1Yhj/Shank3tm1Yhj *
Shank3tm2.1Bux/Shank3tm2.1Bux
Shank3tm2Cmpl/Shank3tm2Cmpl
Shank3tm2Gfng/Shank3tm2Gfng *
Shank3tm3.1Gfng/Shank3tm3.1Gfng
Shank3tm3.2Cmpl/Shank3tm3.2Cmpl *
Shank3tm4.1Gfng/Shank3tm4.1Gfng
Shank3tm5.1Gfng/Shank3tm5.1Gfng
Shank3tm1.1Cya/Shank3+ *
Shank3tm1.1Pfw/Shank3+ *
Shank3tm1.2Bux/Shank3+
Shank3tm2.1Bux/Shank3+
Shank3tm2Cmpl/Shank3+
Shank3tm2Gfng/Shank3+
Shank3tm3.1Gfng/Shank3+
Shank3tm3.2Cmpl/Shank3+
Shank3tm4.1Gfng/Shank3+
Shank3tm5.1Gfng/Shank3tm5.1Gfng
Tg(CAG-cre/Esr1*)1Lbe/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory