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Symbol
Name
ID
Shank3
SH3 and multiple ankyrin repeat domains 3
MGI:1930016
Phenotype annotations related to behavior/neurological
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Schizophrenia
Disease(s) Associated with SHANK3
schizophrenia 15

Mouse Phenotypes
behavior/neurological phenotype
abnormal behavior
photophobia
abnormal conditioned emotional response
enhanced contextual conditioning behavior
abnormal motor learning
abnormal object recognition memory
abnormal long term object recognition memory
abnormal response to new environment
decreased exploration in new environment
abnormal spatial learning
impaired spatial learning
abnormal spatial reference memory
impaired learning
increased aggression towards mice
decreased anxiety-related response
increased anxiety-related response
increased thigmotaxis
abnormal innate avoidance response
abnormal response to novelty
abnormal response to novel object
abnormal allogrooming behavior
increased grooming behavior
abnormal motor capabilities/coordination/movement
impaired righting response
hyporesponsive to tactile stimuli
abnormal startle reflex
decreased startle reflex
increased startle reflex
abnormal motor coordination/balance
impaired coordination
decreased grip strength
decreased vertical activity
increased vertical activity
hyperactivity
induced hyperactivity
hypoactivity
abnormal gait
increased stereotypic behavior
decreased thermal nociceptive threshold
abnormal social/conspecific interaction
abnormal social investigation
social withdrawal
abnormal vocalization
decreased vocalization
environmentally induced seizures
Availability Mouse Genotype
Shank3tm1.1Pfw/Shank3tm1.1Pfw *
Shank3tm1.2Bux/Shank3tm1.2Bux *! !
Shank3tm1.2Yhj/Shank3tm1.2Yhj
Shank3tm1Cmpl/Shank3tm1Cmpl
Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp *
Shank3tm1Gfng/Shank3tm1Gfng *
Shank3tm1Yhj/Shank3tm1Yhj *
Shank3tm2Gfng/Shank3tm2Gfng *
Shank3tm3.1Gfng/Shank3tm3.1Gfng
Shank3tm4.1Gfng/Shank3tm4.1Gfng
Shank3tm5.1Gfng/Shank3tm5.1Gfng
Shank3tm1.1Pfw/Shank3+ *
Shank3tm1.2Bux/Shank3+
Shank3tm3.1Gfng/Shank3+
Shank3tm4.1Gfng/Shank3+
Shank3tm5.1Gfng/Shank3tm5.1Gfng
Tg(CAG-cre/Esr1*)1Lbe/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory